| Tag | Content |
|---|
| CPLM ID | CPLM-010851 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone promoter control protein 2 |
Protein Synonyms/Alias | |
Gene Name | HPC2 |
Gene Synonyms/Alias | YBR215W; YBR1503 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 117 | IPTNRFNKNTVELYQ | acetylation | [1] | | 164 | GSSSFAAKQLKISSL | acetylation | [1] | | 280 | STAQSLGKFNKSTNS | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Component of the HIR complex, which functions as a histone chaperone that cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1. |
Sequence Annotation | MOD_RES 47 47 Phosphoserine.
MOD_RES 49 49 Phosphoserine.
MOD_RES 435 435 Phosphoserine. |
Keyword | Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 625 AA |
Protein Sequence | MDQKAIVLDN SKSGSKQTKS SGKMQTQTDT NAEVLNTDNS IKKETGSDSE DLFNKFSNKK 60
TNRKIPNIAE ELAKNRNYVK GASPSPIIIS GSSSTSPSGP SSSSTNPMGI PTNRFNKNTV 120
ELYQHSPSPV MTTNKTDTEE KRQNNRNMDN KNTPERGSSS FAAKQLKISS LLTISSNEDS 180
KTLHINDTNG NKNSNAASNN IPSAYAELHT EGNSIESLIK PPSSPRNKSL TPKVILPTQN 240
MDGTIAKDPH LGDNTPGILI AKTSSPVNLD VESTAQSLGK FNKSTNSLKA ALTKAPAEKV 300
SLKRSISSVT NSDSNISSSK KPTSEKAKKS SSASAILPKP TTTKTSKKAA SNSSDSTRKK 360
NASNKTTSAI KKESNAGSKL NTVKKENSSL SSIKATEKEK DKGGNSTEAK NSTSNVRKEP 420
TAKSPKRLVA APTVSPPKIL QTAETKAKEP SILIDVPLYQ ADTNDYLDEN GQVIFNLSTL 480
IKEKYHPKSK ELAQLKDSKR NLLMQLSDHS NGSLEKEKDE EGDVIELDDD EDMEEDEGEI 540
DTETNTVTTT ISPKKKSHPM KGKNLIGKYD VEDPFIDDSE LLWEEQRAAT KDGFFVYFGP 600
LIEKGHYASL ERANGTMKRG GVKNK 625 |
Gene Ontology | GO:0000417; C:HIR complex; IDA:SGD. GO:0005634; C:nucleus; IC:SGD. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0006336; P:DNA replication-independent nucleosome assembly; IDA:SGD. GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; IMP:SGD. GO:0006368; P:transcription elongation from RNA polymerase II promoter; IGI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |