CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028858
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone deacetylase 5 
Protein Synonyms/Alias
  
Gene Name
 Hdac5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
164LILRNKEKSKESAIAacetylation[1]
166LRNKEKSKESAIASTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1030 AA 
Protein Sequence
MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG GGGSPSPVEL 60
RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ KQHDHLTRQH EVQLQKHLKQ 120
QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ RLEQQLLILR NKEKSKESAI ASTEVKLRLQ 180
EFLLSKSKEP TPGGLNHSLP QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS 240
RDDFPLRKTA SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS 300
SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP NQFSLYTSPS 360
LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR QGGTLTGKFM STSSIPGCLL 420
GVALEGDTSP HGHASLLQHV LLLEQARQQS TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP 480
RHRPLSRTQS SPLPQSPQAL QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH 540
PEETEEELTE QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG 600
ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT QSSPAAPGSM 660
KSPTDQPTVV KHLFTTGPIS QKMYAMLPCG GIGVDSDTVW NEMHSSSAVR MAVGCLVELA 720
FKVAAGELKN GFAIIRPPGH HAEESTAMGF CFFNSVAITA KLLQQKLSVG KVLIVDWDIH 780
HGNGTQQAFY NDPSVLYISL HRYDNGNFFP GSGAPEEVGG GPGVGYNVNV AWTGGVDPPI 840
GDVEYLTAFR TVVMPIAQEF SPDVVLVSAG FDAVEGHLSP LGGYSVTARC FGHLTRQLMT 900
LAGGRVVLAL EGGHDLTAIC DASEACVSAL LSVELQPLDE AVLQQKPSVN AVATLEKVIE 960
IQSKHWSCVQ RFAAGLGCSL REAQTGEKEE AETVSAMALL SVGAEQAQAV ATQEHSPRPA 1020
EEPMEQEPAL 1030 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0000118; C:histone deacetylase complex; IEA:InterPro.
 GO:0016604; C:nuclear body; IDA:MGI.
 GO:0004407; F:histone deacetylase activity; IEA:InterPro.
 GO:0003714; F:transcription corepressor activity; IDA:MGI.
 GO:0007507; P:heart development; IGI:MGI.
 GO:0016575; P:histone deacetylation; IEA:GOC.
 GO:0033555; P:multicellular organismal response to stress; IMP:MGI.
 GO:0045668; P:negative regulation of osteoblast differentiation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0002076; P:osteoblast development; IMP:MGI.
 GO:0048742; P:regulation of skeletal muscle fiber development; IGI:MGI.
 GO:0042220; P:response to cocaine; IDA:MGI. 
Interpro
 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom.
 IPR024643; Hist_deacetylase_Gln_rich_N.
 IPR017320; Histone_deAcase_II_euk. 
Pfam
 PF12203; HDAC4_Gln
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01270; HDASUPER.