Tag | Content |
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CPLM ID | CPLM-019695 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myosin heavy chain, non-muscle |
Protein Synonyms/Alias | Myosin II; Non-muscle MHC; Zipper protein |
Gene Name | zip |
Gene Synonyms/Alias | CG15792 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
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58 | DRNDPELKYLSVERN | acetylation | [1] | 125 | ILRDDIQKMNPPKFD | acetylation | [1] | 742 | RTVSHLYKEQLAKLM | acetylation | [1] | 1680 | EKRRGLVKQLRDLET | acetylation | [1] |
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Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis. |
Sequence Annotation | DOMAIN 1 869 Myosin head-like. DOMAIN 870 899 IQ. NP_BIND 225 232 ATP. REGION 250 260 25 kDa/50 kDa junction. REGION 722 734 50 kDa/20 kDa junction. REGION 745 767 Actin-binding. REGION 782 798 Reactive sulfhydryl/actin-binding. REGION 1343 2057 Light meromyosin (LMM). REGION 1343 2010 Alpha-helical tailpiece (LMM). REGION 2011 2057 Globular tailpiece. MOD_RES 2021 2021 Phosphoserine. MOD_RES 2022 2022 Phosphoserine. |
Keyword | Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2057 AA |
Protein Sequence | MKSAWLALKS KSALHPKSEY PVSNIHYPKA ANYRQTRNYL EIAAKMSEEV DRNDPELKYL 60 SVERNQFNPI RPRRPSGHRS VLVWVPHENQ GFVAASIKRE HGDEVEVELA ETGKRVMILR 120 DDIQKMNPPK FDKVEDMAEL TCLNEASVLH NIKDRYYSGL IYTYSGLFCV VVNPYKKLPI 180 YTEKIMERYK GIKRHEVPPH VFAITDSAYR NMLGDREDQS ILCTGESGAG KTENTKKVIQ 240 FLAYVAASKP KGSGAVPHPA VLINFSVNTN KYIKVKIMAQ NQNQTIEVVN GLKMVEVNSN 300 CQEGELEQQL LQANPILEAF GNAKTVKNDN SSRFGKFIRI NFDASGFISG ANIETYLLEK 360 SRAIRQAKDE RTFHIFYQLL AGATPEQREK FILDDVKSYA FLSNGSLPVP GVDDYAEFQA 420 TVKSMNIMGM TSEDFNSIFR IVSAVLLFGS MKFRQERNND QATLPDNTVA QKIAHLLGLS 480 VTDMTRAFLT PRIKVGRDFV TKAQTKEQVE FAVEAIAKAC YERMFKWLVN RINRSLDRTK 540 RQGASFIGIL DMAGFEIFEL NSFEQLCINY TNEKLQQLFN HTMFILEQEE YQREGIEWKF 600 IDFGLDLQPT IDLIDKPGGI MALLDEECWF PKATDKTFVD KLVSAHSMHP KFMKTDFRGV 660 ADFAIVHYAG RVDYSAAKWL MKNMDPLNEN IVSLLQGSQD PFVVNIWKDA EIVGMAQQAL 720 TDTQFGARTR KGMFRTVSHL YKEQLAKLMD TLRNTNPNFV RCIIPNHEKR AGKIDAPLVL 780 DQLRCNGVLE GIRICRQGFP NRIPFQEFRQ RYELLTPNVI PKGFMDGKKA CEKMIQALEL 840 DSNLYRVGQS KIFFRAGVLA HLEEERDFKI SDLIVNFQAF CRGFLARRNY QKRLQQLNAI 900 RIIQRNCAAY LKLRNWQWWR LYTKVKPLLE VTKQEEKLVQ KEDELKQVRE KLDTLAKNTQ 960 EYERKYQQAL VEKTTLAEQL QAEIELCAEA EESRSRLMAR KQELEDMMQE LETRIEEEEE 1020 RVLALGGEKK KLELNIQDLE EQLEEEEAAR QKLQLEKVQL DAKIKKYEED LALTDDQNQK 1080 LLKEKKLLEE RANDLSQTLA EEEEKAKHLA KLKAKHEATI TELEERLHKD QQQRQESDRS 1140 KRKIETEVAD LKEQLNERRV QVDEMQAQLA KREEELTQTL LRIDEESATK ATAQKAQREL 1200 ESQLAEIQED LEAEKAARAK AEKVRRDLSE ELEALKNELL DSLDTTAAQQ ELRSKREQEL 1260 ATLKKSLEEE TVNHEGVLAD MRHKHSQELN SINDQLENLR KAKTVLEKAK GTLEAENADL 1320 ATELRSVNSS RQENDRRRKQ AESQIAELQV KLAEIERARS ELQEKCTKLQ QEAENITNQL 1380 EEAELKASAA VKSASNMESQ LTEAQQLLEE ETRQKLGLSS KLRQIESEKE ALQEQLEEDD 1440 EAKRNYERKL AEVTTQMQEI KKKAEEDADL AKELEEGKKR LNKDIEALER QVKELIAQND 1500 RLDKSKKKIQ SELEDATIEL EAQRTKVLEL EKKQKNFDKI LAEEKAISEQ IAQERDTAER 1560 EAREKETKVL SVSRELDEAF DKIEDLENKR KTLQNELDDL ANTQGTADKN VHELEKAKRA 1620 LESQLAELKA QNEELEDDLQ LTEDAKLRLE VNMQALRSQF ERDLLAKEEG AEEKRRGLVK 1680 QLRDLETELD EERKQRTAAV ASKKKLEGDL KEIETTMEMH NKVKEDALKH AKKLQAQVKD 1740 ALRDAEEAKA AKEELQALSK EADGKVKALE AEVLQLTEDL ASSERARRAA ETERDELAEE 1800 IANNANKGSL MIDEKRRLEA RIATLEEELE EEQSNSEVLL DRSRKAQLQI EQLTTELANE 1860 KSNSQKNENG RALLERQNKE LKAKLAEIET AQRTKVKATI ATLEAKIANL EEQLENEGKE 1920 RLLQQKANRK MDKKIKELTM NIEDERRHVD QHKEQMDKLN SRIKLLKRNL DETEEELQKE 1980 KTQKRKYQRE CEDMIESQEA MNREINSLKT KLRRTGGIGL SSSRLTGTPS SKRAGGGGGS 2040 DDSSVQDESL DGEDSAN 2057 |
Gene Ontology | |
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