CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023507
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proline dehydrogenase 1, mitochondrial 
Protein Synonyms/Alias
 Proline oxidase 
Gene Name
 Prodh 
Gene Synonyms/Alias
 Pro1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
178SGANKREKQYQVHPAacetylation[1, 2]
356EEEEQQMKRMLQRMDacetylation[1]
367QRMDVLAKKAKEAGVacetylation[1, 2, 3]
404QRRFNVDKPFIFNTFacetylation[1]
485NYVLEELKHSTKAEVacetylation[1]
572LENSSIMKGAQRERQubiquitination[4]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Converts proline to delta-1-pyrroline-5-carboxylate. 
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Proline metabolism; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 599 AA 
Protein Sequence
MALKRVFLLR SVAPRVAALS TKPQAQEQPP ASPEALRGCG AAKAVRPPVP AVDFTNTQEA 60
YRSRRSWELV RNLLVLRLCA SPVLLAHHEQ LFQVARKLLG QRMFERLMKM TFYGHFVAGE 120
DQESIRPLIR HNKAFGVGFI LDYGVEEDLS PEEAERKEME SCTSEAERDG SGANKREKQY 180
QVHPAFGDRR DGVISARTYF YANEAKCDNY MENLLQCIKA SGGASDGGFS AIKLTALGRP 240
QFLLQFSDVL TRWRRFFHQM AAEQGQAGRA AVDTKLEVAV LQDSIAKMGI ASRAEIEGWF 300
TPETLGVSGT VDLLDWNSLI DSRTRLSRHL VVPNVQTGQL EPLLSRFTEE EEQQMKRMLQ 360
RMDVLAKKAK EAGVRLMIDA EQSYFQPAIS RLTLEMQRRF NVDKPFIFNT FQCYLKDAYD 420
NVTLDMELAR REGWCFGAKL VRGAYMAQER VRAAEIGYED PINPTYEATN AMYHRCLNYV 480
LEELKHSTKA EVMVASHNED TVHFTLCRMK EIGLHPADGQ VCFGQLLGMC DQISFPLGQA 540
GFPVYKYVPY GPVMEVLPYL SRRALENSSI MKGAQRERQL LWQELRRRLR TGSLFHHPA 599 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0071949; F:FAD binding; ISS:UniProtKB.
 GO:0004657; F:proline dehydrogenase activity; ISS:UniProtKB.
 GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.
 GO:0010133; P:proline catabolic process to glutamate; IEA:UniProtKB-UniPathway. 
Interpro
 IPR002872; Proline_DH.
 IPR015659; Proline_oxidase. 
Pfam
 PF01619; Pro_dh 
SMART
  
PROSITE
  
PRINTS