CPLM-006439

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-006439

UniProt Accession

CAH5A_HUMAN; P35218; B2RPF2

Genbank Protein ID

L19297; U25134; S80181; S80175; S80176; S80177; S80178; S80240; S80180; CH471114; BC137405; BC137411

Genbank Nucleotide ID

AAA02890.1; AAC99806.1; AAB47048.1; AAB47048.1; AAB47048.1; AAB47048.1; AAB47048.1; AAB47048.1; AAB47048.1; EAW95372.1; AAI37406.1; AAI37412.1

Protein Name

Carbonic anhydrase 5A, mitochondrial

Protein Synonyms/Alias

Carbonate dehydratase VA; Carbonic anhydrase VA; CA-VA

Gene Name

CA5A

Gene Synonyms/Alias

CA5

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
291	LQPLMNRKVWASFQA	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Reversible hydration of carbon dioxide. Low activity.

Sequence Annotation

REGION 235 236 Substrate binding (By similarity).
ACT_SITE 164 164 By similarity.
ACT_SITE 167 167 Probable.
METAL 130 130 Zinc; catalytic (By similarity).
METAL 132 132 Zinc; catalytic (By similarity).
METAL 155 155 Zinc; catalytic (By similarity).

Keyword

Complete proteome; Direct protein sequencing; Lyase; Metal-binding; Mitochondrion; Reference proteome; Transit peptide; Zinc.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

305 AA

Protein Sequence

MLGRNTWKTS AFSFLVEQMW APLWSRSMRP GRWCSQRSCA WQTSNNTLHP LWTVPVSVPG 60
GTRQSPINIQ WRDSVYDPQL KPLRVSYEAA SCLYIWNTGY LFQVEFDDAT EASGISGGPL 120
ENHYRLKQFH FHWGAVNEGG SEHTVDGHAY PAELHLVHWN SVKYQNYKEA VVGENGLAVI 180
GVFLKLGAHH QTLQRLVDIL PEIKHKDARA AMRPFDPSTL LPTCWDYWTY AGSLTTPPLT 240
ESVTWIIQKE PVEVAPSQLS AFRTLLFSAL GEEEKMMVNN YRPLQPLMNR KVWASFQATN 300
EGTRS 305

Gene Ontology

GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0004089; F:carbonate dehydratase activity; TAS:ProtInc.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0015701; P:bicarbonate transport; TAS:Reactome.
GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.

Interpro

IPR018437; CA-V_mt.
IPR001148; Carbonic_anhydrase_a.
IPR023561; Carbonic_anhydrase_a-class.
IPR018338; Carbonic_anhydrase_a-class_CS.

Pfam

PF00194; Carb_anhydrase

SMART

SM01057; Carb_anhydrase

PROSITE

PS00162; ALPHA_CA_1
PS51144; ALPHA_CA_2

PRINTS