CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031259
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exportin-2 
Protein Synonyms/Alias
 Uncharacterized protein; cDNA FLJ53202, highly similar to Exportin-2 
Gene Name
 CSE1L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
129TLTSICEKVIVPNMEubiquitination[1]
223LVTSLASKAQTQKHGubiquitination[2, 3]
264VNEFPVLKADGIKYIubiquitination[3, 4]
357SENEYIMKAIMRSFSacetylation[5, 6]
509IASAAADKIPGLLGVubiquitination[2]
607MFGMVLEKIIIPEIQubiquitination[2]
615IIIPEIQKVSGNVEKacetylation[6]
631ICAVGITKLLTECPPubiquitination[7, 8]
708GQMVNNPKIHLAQSLubiquitination[2]
717HLAQSLHKLSTACPGubiquitination[2, 7]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [8] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 754 AA 
Protein Sequence
MLSNLNFQDL PEFFEDNMET WMNNFHTLLT LDNKLLQTDD EEEAGLLELL KSQICDNAAL 60
YAQKYDEEFQ RYLPRFVTAI WNLLVTTGQE VKYDLLVSNA IQFLASVCER PHYKNLFEDQ 120
NTLTSICEKV IVPNMEFRAA DEEAFEDNSE EYIRRDLEGS DIDTRRRAAC DLVRGLCKFF 180
EGPVTGIFSG YVNSMLQEYA KNPSVNWKHK DAAIYLVTSL ASKAQTQKHG ITQANELVNL 240
TEFFVNHILP DLKSANVNEF PVLKADGIKY IMIFRNQVPK EHLLVSIPLL INHLQAESIV 300
VHTYAAHALE RLFTMRGPNN ATLFTAAEIA PFVEILLTNL FKALTLPGSS ENEYIMKAIM 360
RSFSLLQEAI IPYIPTLITQ LTQKLLAVSK NPSKPHFNHY MFEAICLSIR ITCKANPAAV 420
VNFEEALFLV FTEILQNDVQ EFIPYVFQVM SLLLETHKND IPSSYMALFP HLLQPVLWER 480
TGNIPALVRL LQAFLERGSN TIASAAADKI PGLLGVFQKL IASKANDHQG FYLLNSIIEH 540
MPPESVDQYR KQIFILLFQR LQNSKTTKFI KSFLVFINLY CIKYGALALQ EIFDGIQPKM 600
FGMVLEKIII PEIQKVSGNV EKKICAVGIT KLLTECPPMM DTEYTKLWTP LLQSLIGLFE 660
LPEDDTIPDE EHFIDIEDTP GYQTAFSQLA FAGKKEHDPV GQMVNNPKIH LAQSLHKLST 720
ACPGRVPSMV STSLNAEALQ YLQGYLQAAS VTLL 754 
Gene Ontology
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR005043; CAS_CSE1_C.
 IPR013713; Exportin/Importin_Cse1-like. 
Pfam
 PF03378; CAS_CSE1
 PF08506; Cse1 
SMART
  
PROSITE
  
PRINTS