| Tag | Content |
|---|
| CPLM ID | CPLM-004725 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Keratin, type I cytoskeletal 19 |
Protein Synonyms/Alias | Cytokeratin-19; CK-19; Keratin-19; K19 |
Gene Name | Krt19 |
Gene Synonyms/Alias | Krt1-19 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 171 | AADDFRTKFETEHAL | ubiquitination | [1] | | 219 | EELAYLKKNHEEEIT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). |
Sequence Annotation | REGION 1 82 Head.
REGION 83 390 Rod.
REGION 83 118 Coil 1A.
REGION 119 136 Linker 1.
REGION 137 228 Coil 1B.
REGION 229 251 Linker 12.
REGION 247 393 Necessary for interaction with PNN (By
REGION 252 390 Coil 2.
REGION 391 403 Rod-like helical tail.
MOD_RES 35 35 Phosphoserine (By similarity).
MOD_RES 394 394 Phosphotyrosine. |
Keyword | Coiled coil; Complete proteome; Intermediate filament; Keratin; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 403 AA |
Protein Sequence | MTSYSYRQTS AMSSFGGTGG GSVRIGSGGV FRAPSIHGGS GGRGVSVSST RFVTSSSGSY 60
GGVRGGSFSG TLAVSDGLLS GNEKITMQNL NDRLASYLDK VRALEQANGE LEVKIRDWYQ 120
KQGPGPSRDY NHYFKTIEDL RDKILGATID NSKIVLQIDN ARLAADDFRT KFETEHALRL 180
SVEADINGLR RVLDELTLAR TDLEMQIESL KEELAYLKKN HEEEITALRS QVGGQVSVEV 240
DSTPGVDLAK ILSEMRSQYE IMAEKNRKDA EATYLARIEE LNTQVAVHSE QIQISKTEVT 300
DLRRTLQGLE IELQSQLSMK AALEGTLAET EARYGVQLSQ IQSVISGFEA QLSDVRADIE 360
RQNQEYKQLM DIKSRLEQEI ATYRSLLEGQ EAHYNNLPTP KAI 403 |
Gene Ontology | GO:0043034; C:costamere; IEA:Compara. GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Compara. GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. GO:0042383; C:sarcolemma; IDA:MGI. GO:0030018; C:Z disc; IDA:MGI. GO:0008307; F:structural constituent of muscle; IEA:Compara. GO:0060706; P:cell differentiation involved in embryonic placenta development; IGI:MGI. GO:0043627; P:response to estrogen stimulus; IEA:Compara. GO:0045214; P:sarcomere organization; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |