CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021661
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uncharacterized protein KIAA1586 
Protein Synonyms/Alias
  
Gene Name
 KIAA1586 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
95TENNEVSKNHCRLSKubiquitination[1]
126KPSLSSKKEIDNLVLubiquitination[1]
162KEGKLGCKDCSAVRHubiquitination[1]
196VTPNGSNKTTRQASLubiquitination[1]
218DVSKAHGKIQDLLKEubiquitination[1]
224GKIQDLLKESTNDSIubiquitination[1]
241LVHKQNNKNIDATVKubiquitination[1]
275GARELQEKNGEVNCLubiquitination[1, 2]
435DDSISEIKQINHLKIubiquitination[1, 3, 4, 5]
460QPNKNQTKLLGTVAKubiquitination[1]
467KLLGTVAKELETEIIubiquitination[1]
475ELETEIIKIGRVMGPubiquitination[1]
568IRALENLKIGTGKYEubiquitination[4]
573NLKIGTGKYESQIEDubiquitination[1]
663FHLCKILKYEVDLNDubiquitination[1]
680EFVNNNIKSNNVSIPubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 787 AA 
Protein Sequence
MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPSR PVLEYIDLVC GDDENPSAYY 60
SDILFPKMPK RQGDFLHFLN VKKVKTDTEN NEVSKNHCRL SKAKEPHFEY IEQPIIEEKP 120
SLSSKKEIDN LVLPDCWNEK QAFMFTEQYK WLEIKEGKLG CKDCSAVRHL GSKAEKHVHV 180
SKEWIAYLVT PNGSNKTTRQ ASLRKKIREH DVSKAHGKIQ DLLKESTNDS ICNLVHKQNN 240
KNIDATVKVF NTVYSLVKHN RPLSDIEGAR ELQEKNGEVN CLNTRYSATR IAEHIAKEMK 300
MKIFKNIIEE NAKICIIIDE ASTVSKKTTL VIYLQCTIQS APAPVMLFVA LKELVSTIAE 360
CIVNTLLTTL NDCGFTNEYL KANLIAFCSD GANTILGRKS GVATKLLENF PEIIIWNCLN 420
HRLQLSLDDS ISEIKQINHL KIFIDKIYSI YHQPNKNQTK LLGTVAKELE TEIIKIGRVM 480
GPRWAACSLQ AATAVWHAYP ILYMHFSHSY SGLAKRLANI NFLQDLALMI DILEEFSVLS 540
TALQSRSTNI KKAQKLIKRT IRALENLKIG TGKYESQIED LIKSDKFKDI PFNKNNKFNA 600
LPRSILLDNI IQHMNLRLLS DRNHEDIFNY FDLLEPSTWP YEEITSPWIA GEKTLFHLCK 660
ILKYEVDLND FREFVNNNIK SNNVSIPTTI YKAKKIVSTI AINSAEAERG FNLMNIICTR 720
VRNSLTIDHV SDLMTINLLG KELADWDATP FVKSWSNCNH RLATDTRVRQ KSTKVFHENQ 780
LAIWNLK 787 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR012337; RNaseH-like_dom. 
Pfam
  
SMART
  
PROSITE
  
PRINTS