| Tag | Content |
|---|
| CPLM ID | CPLM-007078 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Copper-transporting ATPase |
Protein Synonyms/Alias | Cu(2+)-ATPase |
Gene Name | CCC2 |
Gene Synonyms/Alias | YDR270W; D9954.6 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 168 | TVILKVTKAFEDESP | ubiquitination | [1] | | 967 | SHGISDFKSKFSIGN | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles. |
Sequence Annotation | DOMAIN 3 68 HMA 1.
DOMAIN 81 147 HMA 2.
ACT_SITE 627 627 4-aspartylphosphate intermediate (By
METAL 13 13 Copper.
METAL 16 16 Copper.
METAL 91 91 Copper (Potential).
METAL 94 94 Copper (Potential).
METAL 838 838 Magnesium (By similarity).
METAL 842 842 Magnesium (By similarity). |
Keyword | 3D-structure; ATP-binding; Complete proteome; Copper; Copper transport; Golgi apparatus; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1004 AA |
Protein Sequence | MREVILAVHG MTCSACTNTI NTQLRALKGV TKCDISLVTN ECQVTYDNEV TADSIKEIIE 60
DCGFDCEILR DSEITAISTK EGLLSVQGMT CGSCVSTVTK QVEGIEGVES VVVSLVTEEC 120
HVIYEPSKTT LETAREMIED CGFDSNIIMD GNGNADMTEK TVILKVTKAF EDESPLILSS 180
VSERFQFLLD LGVKSIEISD DMHTLTIKYC CNELGIRDLL RHLERTGYKF TVFSNLDNTT 240
QLRLLSKEDE IRFWKKNSIK STLLAIICML LYMIVPMMWP TIVQDRIFPY KETSFVRGLF 300
YRDILGVILA SYIQFSVGFY FYKAAWASLK HGSGTMDTLV CVSTTCAYTF SVFSLVHNMF 360
HPSSTGKLPR IVFDTSIMII SYISIGKYLE TLAKSQTSTA LSKLIQLTPS VCSIISDVER 420
NETKEIPIEL LQVNDIVEIK PGMKIPADGI ITRGESEIDE SLMTGESILV PKKTGFPVIA 480
GSVNGPGHFY FRTTTVGEET KLANIIKVMK EAQLSKAPIQ GYADYLASIF VPGILILAVL 540
TFFIWCFILN ISANPPVAFT ANTKADNFFI CLQTATSVVI VACPCALGLA TPTAIMVGTG 600
VGAQNGVLIK GGEVLEKFNS ITTFVFDKTG TLTTGFMVVK KFLKDSNWVG NVDEDEVLAC 660
IKATESISDH PVSKAIIRYC DGLNCNKALN AVVLESEYVL GKGIVSKCQV NGNTYDICIG 720
NEALILEDAL KKSGFINSNV DQGNTVSYVS VNGHVFGLFE INDEVKHDSY ATVQYLQRNG 780
YETYMITGDN NSAAKRVARE VGISFENVYS DVSPTGKCDL VKKIQDKEGN NKVAVVGDGI 840
NDAPALALSD LGIAISTGTE IAIEAADIVI LCGNDLNTNS LRGLANAIDI SLKTFKRIKL 900
NLFWALCYNI FMIPIAMGVL IPWGITLPPM LAGLAMAFSS VSVVLSSLML KKWTPPDIES 960
HGISDFKSKF SIGNFWSRLF STRAIAGEQD IESQAGLMSN EEVL 1004 |
Gene Ontology | GO:0016021; C:integral to membrane; ISM:SGD. GO:0012510; C:trans-Golgi network transport vesicle membrane; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0019829; F:cation-transporting ATPase activity; IDA:SGD. GO:0005507; F:copper ion binding; IDA:SGD. GO:0004008; F:copper-exporting ATPase activity; IEA:EC. GO:0006879; P:cellular iron ion homeostasis; IMP:SGD. GO:0060003; P:copper ion export; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |