CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001925
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 H-2 class I histocompatibility antigen, D-B alpha chain 
Protein Synonyms/Alias
 H-2D(B) 
Gene Name
 H2-D1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
55SVGYVDNKEFVRFDSubiquitination[1]
170AAQITRRKWEQSGAAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Involved in the presentation of foreign antigens to the immune system. 
Sequence Annotation
 DOMAIN 209 297 Ig-like C1-type.
 REGION 25 114 Alpha-1.
 REGION 115 206 Alpha-2.
 REGION 207 298 Alpha-3.
 REGION 299 309 Connecting peptide.
 CARBOHYD 110 110 N-linked (GlcNAc...).
 CARBOHYD 200 200 N-linked (GlcNAc...) (Probable).
 CARBOHYD 280 280 N-linked (GlcNAc...).
 DISULFID 125 188
 DISULFID 227 283
 CROSSLNK 353 353 Glycyl serine ester (Ser-Gly) (interchain  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MGAMAPRTLL LLLAAALAPT QTRAGPHSMR YFETAVSRPG LEEPRYISVG YVDNKEFVRF 60
DSDAENPRYE PRAPWMEQEG PEYWERETQK AKGQEQWFRV SLRNLLGYYN QSAGGSHTLQ 120
QMSGCDLGSD WRLLRGYLQF AYEGRDYIAL NEDLKTWTAA DMAAQITRRK WEQSGAAEHY 180
KAYLEGECVE WLHRYLKNGN ATLLRTDSPK AHVTHHPRSK GEVTLRCWAL GFYPADITLT 240
WQLNGEELTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVYHEGL PEPLTLRWEP 300
PPSTDSYMVI VAVLGVLGAM AIIGAVVAFV MKRRRNTGGK GGDYALAPGS QSSEMSLRDC 360
KA 362 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 
Pfam
 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 
SMART
 SM00407; IGc1 
PROSITE
 PS50835; IG_LIKE
 PS00290; IG_MHC 
PRINTS
 PR01638; MHCCLASSI.