CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027928
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock protein 70 
Protein Synonyms/Alias
 Heat shock protein, putative 
Gene Name
 HSP70 
Gene Synonyms/Alias
 TGGT1_112840; TGVEG_021100 
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
188AIAYGLDKKGCGEMNacetylation[1, 2]
247DFCVQDFKRKNRGKDacetylation[1]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907]
 [2] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Oxidoreductase; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 667 AA 
Protein Sequence
MADSPAVGID LGTTYSCVGV WKNDAVEIIA NDQGNRTTPS YVAFTDTERL VGDAAKNQVA 60
RNPENTIFDA KRLIGRKFDD PSVQSDMKHW PFKVIAGPGD KPLIEVTYQG EKKTFHPEEV 120
SAMVLGKMKE IAEAYLGKEV KEAVITVPAY FNDSQRQATK DAGTIAGLSV LRIINEPTAA 180
AIAYGLDKKG CGEMNVLIFD MGGGTFDVSL LTIEDGIFEV KATAGDTHLG GEDFDNRLVD 240
FCVQDFKRKN RGKDISTNSR ALRRLRTQCE RTKRTLSSST QATIEIDSLF EGIDYSVSIS 300
RARFEELCMD YFRNSLLPVE KVLKDSGIDK RSVSEVVLVG GSTRIPKIQQ LITDFFNGKE 360
PCRSINPDEA VAYGAAVQAA ILKGVTSSQV QDLLLLDVAP LSLGLETAGG VMTKLIERNT 420
TIPTKKSQTF TTYADNQPGV LIQVYEGERA MTKDNNLLGK FHLDGIPPAP RGVPQIEVTF 480
DIDANGIMNV TAQDKSTGKS NQITITNDKG RLSASEIDRM VQEAEKYKAE DEQNKHRVEA 540
KNGLENYCYH MRQTLDDEKL KDKISSEDRD TANKAIQEAL DWLDKNQLAE KEEFEAKQKE 600
VESVCTPIIT KLYQAGAAAG GMPGGMGGMP GGMGGMPGGM GGMPGGMGGM PGAGMGGSGG 660
PTVEEVD 667 
Gene Ontology
 GO:0032440; F:2-alkenal reductase [NAD(P)] activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.