| Tag | Content |
|---|
| CPLM ID | CPLM-003457 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aerobic respiration control sensor protein ArcB |
Protein Synonyms/Alias | |
Gene Name | arcB |
Gene Synonyms/Alias | b3210; JW5536 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 93 | RLSRLVQKLEEMRER | acetylation | [1] | | 193 | LLTGKSEKQLVHLKP | acetylation | [1] | | 218 | KVIETDEKVFRHNVS | acetylation | [1] | | 319 | ELTAEQEKYLKTIHV | acetylation | [1] | | 547 | VARSVLEKLGNSVDV | acetylation | [1] | | 709 | SNLTAQDKKGIVEEG | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576. |
Sequence Annotation | DOMAIN 153 223 PAS.
DOMAIN 226 278 PAC.
DOMAIN 289 507 Histidine kinase.
DOMAIN 527 643 Response regulatory.
DOMAIN 678 771 HPt.
MOD_RES 292 292 Phosphohistidine; by autocatalysis.
MOD_RES 576 576 4-aspartylphosphate (Probable).
MOD_RES 717 717 Phosphohistidine (Probable). |
Keyword | 3D-structure; ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Transferase; Transmembrane; Transmembrane helix; Two-component regulatory system. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 778 AA |
Protein Sequence | MKQIRLLAQY YVDLMMKLGL VRFSMLLALA LVVLAIVVQM AVTMVLHGQV ESIDVIRSIF 60
FGLLITPWAV YFLSVVVEQL EESRQRLSRL VQKLEEMRER DLSLNVQLKD NIAQLNQEIA 120
VREKAEAELQ ETFGQLKIEI KEREETQIQL EQQSSFLRSF LDASPDLVFY RNEDKEFSGC 180
NRAMELLTGK SEKQLVHLKP ADVYSPEAAA KVIETDEKVF RHNVSLTYEQ WLDYPDGRKA 240
CFEIRKVPYY DRVGKRHGLM GFGRDITERK RYQDALERAS RDKTTFISTI SHELRTPLNG 300
IVGLSRILLD TELTAEQEKY LKTIHVSAVT LGNIFNDIID MDKMERRKVQ LDNQPVDFTS 360
FLADLENLSA LQAQQKGLRF NLEPTLPLPH QVITDGTRLR QILWNLISNA VKFTQQGQVT 420
VRVRYDEGDM LHFEVEDSGI GIPQDELDKI FAMYYQVKDS HGGKPATGTG IGLAVSRRLA 480
KNMGGDITVT SEQGKGSTFT LTIHAPSVAE EVDDAFDEDD MPLPALNVLL VEDIELNVIV 540
ARSVLEKLGN SVDVAMTGKA ALEMFKPGEY DLVLLDIQLP DMTGLDISRE LTKRYPREDL 600
PPLVALTANV LKDKQEYLNA GMDDVLSKPL SVPALTAMIK KFWDTQDDEE STVTTEENSK 660
SEALLDIPML EQYLELVGPK LITDGLAVFE KMMPGYVSVL ESNLTAQDKK GIVEEGHKIK 720
GAAGSVGLRH LQQLGQQIQS PDLPAWEDNV GEWIEEMKEE WRHDVEVLKA WVAKATKK 778 |
Gene Ontology | GO:0016021; C:integral to membrane; IDA:EcoCyc. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0009927; F:histidine phosphotransfer kinase activity; IDA:EcoCyc. GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro. GO:0000155; F:phosphorelay sensor kinase activity; IDA:EcoCyc. GO:0035556; P:intracellular signal transduction; IEA:GOC. GO:0046777; P:protein autophosphorylation; IDA:EcoCyc. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |