UniProt Accession

 RS14_HUMAN; P62263; B2R5G5; D3DQG5; P06366; Q5BJI0 

Genbank Protein ID

 M13934; AF116710; AK312179; CH471062; CH471062; CH471062; CH471062; BC001126; BC003401; BC006784; BC020515; BC091474 

Genbank Nucleotide ID

 AAB59505.1; AAF71130.1; BAG35112.1; EAW61723.1; EAW61724.1; EAW61725.1; EAW61726.1; AAH01126.1; AAH03401.1; AAH06784.1; AAH20515.1; AAH91474.1 

Protein Name

 40S ribosomal protein S14 

Protein Synonyms/Alias

  

Gene Name

 RPS14 

Gene Synonyms/Alias

 PRO2640 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	VTGGMKVKADRDESS	ubiquitination	[1, 2, 3, 4, 5]
86	QDVAQRCKELGITAL	ubiquitination	[1, 3, 4, 5]
96	GITALHIKLRATGGN	ubiquitination	[1, 3, 4, 5]
106	ATGGNRTKTPGPGAQ	ubiquitination	[1, 2, 3, 4, 5, 6]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

  

Sequence Annotation

 MOD_RES 133 133 Phosphothreonine.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 151 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0048027; F:mRNA 5'-UTR binding; IDA:UniProtKB.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0045182; F:translation regulator activity; IMP:UniProtKB.
 GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB.
 GO:0030490; P:maturation of SSU-rRNA; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0000028; P:ribosomal small subunit assembly; IMP:UniProtKB.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR001971; Ribosomal_S11.
 IPR018102; Ribosomal_S11_CS. 

Pfam

 PF00411; Ribosomal_S11 

SMART

  

PROSITE

 PS00054; RIBOSOMAL_S11 

PRINTS