Tag | Content |
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CPLM ID | CPLM-012968 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Heterogeneous nuclear ribonucleoprotein D-like |
Protein Synonyms/Alias | hnRNP D-like; hnRNP DL |
Gene Name | Hnrpdl |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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209 | GSGKCEIKVAQPKEV | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence (By similarity). |
Sequence Annotation | DOMAIN 51 133 RRM 1. DOMAIN 136 215 RRM 2. REGION 245 322 Necessary for interaction with TNPO1 (By MOD_RES 64 64 N6-methyllysine (By similarity). MOD_RES 119 119 N6-acetyllysine (By similarity). MOD_RES 144 144 Phosphoserine (By similarity). MOD_RES 310 310 Dimethylated arginine; alternate (By MOD_RES 310 310 Omega-N-methylated arginine; alternate |
Keyword | Acetylation; Activator; Complete proteome; Cytoplasm; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 322 AA |
Protein Sequence | MTGTARSALP LPQSPARALR PSGAARAAPS LSPSRFSACP LDPSSFPTSG NKMFIGGLSW 60 DTSKKDLTEY LSRFGEVVDC TIKTDPVTGR SRGFGFVLFK DAASVDKVLE LKEHKLDGKL 120 IDPKRAKALK GKEPPKKVFV GGLSPDTSEE QIKEYFGAFG EIENIELPMD TKTNERRGFC 180 FITYTDEEPV KKLLESRYHQ IGSGKCEIKV AQPKEVYRQQ QQQQKGGRGA AAGGRGGARG 240 RGRGQGQNWN QGFNNYYDQG YGNYNSAYGD ESYSGYGGYD YTGYNYGSYG YGQGYTDYSG 300 QQSTYGKASR GGGNHQNNYQ PY 322 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003690; F:double-stranded DNA binding; IEA:Compara. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0008143; F:poly(A) RNA binding; IEA:Compara. GO:0034046; F:poly(G) RNA binding; IEA:Compara. GO:0003697; F:single-stranded DNA binding; IEA:Compara. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |