UniProt Accession

 TCP4_RAT; Q63396; Q5M805 

Genbank Protein ID

 BC088346; K02816 

Genbank Nucleotide ID

 AAH88346.1; AAA41758.1 

Protein Name

 Activated RNA polymerase II transcriptional coactivator p15 

Protein Synonyms/Alias

 Positive cofactor 4; PC4; SUB1 homolog; p14 

Gene Name

 Sub1 

Gene Synonyms/Alias

 Pc4; Rpo2tc1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
35	KKQVVPEKPVKKQKP	acetylation	[1]
68	DNMFQIGKMRYVSVR	acetylation	[1]
80	SVRDFKGKILIDIRE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity). 

Sequence Annotation

 REGION 2 50 Regulatory (By similarity).
 REGION 77 101 Interaction with ssDNA (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 13 13 Phosphoserine (By similarity).
 MOD_RES 15 15 Phosphoserine (By similarity).
 MOD_RES 17 17 Phosphoserine (By similarity).
 MOD_RES 19 19 Phosphoserine (By similarity).
 MOD_RES 35 35 N6-acetyllysine (By similarity).
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).  

Keyword

 Acetylation; Activator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003697; F:single-stranded DNA binding; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003173; PC4.
 IPR009044; ssDNA-bd_transcriptional_reg. 

Pfam

 PF02229; PC4 

SMART

  

PROSITE

  

PRINTS