CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035453
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Mthfd2 
Protein Synonyms/Alias
 RCG56426 
Gene Name
 Mthfd2 
Gene Synonyms/Alias
 rCG_56426 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
49RKLAQQIKQEVRQEVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 349 AA 
Protein Sequence
MVSVSLSALA VRLLRPTHGC HSRLQSFHLA AVRNEAVVIS GRKLAQQIKQ EVRQEVEEWV 60
ASGNKRPHLS VILVGDNPAS HSYVLNKTRA AAEVGINSET IVKPASVSEE ELLNSIRTLN 120
DDENVDGLLV QLPLPEHIDE RKICNAVSPD KDVDGFHVIN VGRMCLDQYS MLPATPWGVW 180
EILKRTGIPT LGKNVVVAGR SKNVGMPIAM LLHTDGAHER PGGDATVTIS HRHTPKEQLK 240
KHTILADIVI SAAGIPNLIT ADMIKEGATV IDVGINRVQD PVTAKPKLVG DVDFEGVKKK 300
AGYITPVPGG VGPMTVAMLM KNTIIAAKKV LRPEELEVLK STQRGVATN 349 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0004487; F:methylenetetrahydrofolate dehydrogenase (NAD+) activity; IEA:Compara.
 GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
 GO:0042301; F:phosphate ion binding; IEA:Compara.
 GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
 GO:0046653; P:tetrahydrofolate metabolic process; IEA:Compara. 
Interpro
 IPR016040; NAD(P)-bd_dom.
 IPR000672; THF_DH/CycHdrlase.
 IPR020630; THF_DH/CycHdrlase_cat_dom.
 IPR020867; THF_DH/CycHdrlase_CS.
 IPR020631; THF_DH/CycHdrlase_NAD-bd_dom. 
Pfam
 PF00763; THF_DHG_CYH
 PF02882; THF_DHG_CYH_C 
SMART
  
PROSITE
 PS00766; THF_DHG_CYH_1
 PS00767; THF_DHG_CYH_2 
PRINTS
 PR00085; THFDHDRGNASE.