CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000011
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Unconventional myosin-Ic 
Protein Synonyms/Alias
 Myosin I beta; MMI-beta; MMIb 
Gene Name
 MYO1C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
153LEAFGNAKTLRNDNSubiquitination[1]
369INRSLASKDVESPSWubiquitination[1]
583LVEILQSKEPAYVRCubiquitination[1]
833RSISPEWKQQLQQKAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity). 
Sequence Annotation
 DOMAIN 36 718 Myosin head-like.
 DOMAIN 734 757 IQ 1.
 DOMAIN 758 786 IQ 2.
 NP_BIND 140 147 ATP (Potential).
 MOD_RES 383 383 N6-methyllysine.
 MOD_RES 408 408 Phosphoserine.  
Keyword
 Acetylation; Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Methylation; Motor protein; mRNA transport; Myosin; Nuclear pore complex; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1063 AA 
Protein Sequence
MESALTARDR VGVQDFVLLE NFTSEAAFIE NLRRRFRENL IYTYIGPVLV SVNPYRDLQI 60
YSRQHMERYR GVSFYEVPPH LFAVADTVYR ALRTERRDQA VMISGESGAG KTEATKRLLQ 120
FYAETCPAPE RGGAVRDRLL QSNPVLEAFG NAKTLRNDNS SRFGKYMDVQ FDFKGAPVGG 180
HILSYLLEKS RVVHQNHGER NFHIFYQLLE GGEEETLRRL GLERNPQSYL YLVKGQCAKV 240
SSINDKSDWK VVRKALTVID FTEDEVEDLL SIVASVLHLG NIHFAANEES NAQVTTENQL 300
KYLTRLLSVE GSTLREALTH RKIIAKGEEL LSPLNLEQAA YARDALAKAV YSRTFTWLVG 360
KINRSLASKD VESPSWRSTT VLGLLDIYGF EVFQHNSFEQ FCINYCNEKL QQLFIELTLK 420
SEQEEYEAEG IAWEPVQYFN NKIICDLVEE KFKGIISILD EECLRPGEAT DLTFLEKLED 480
TVKHHPHFLT HKLADQRTRK SLGRGEFRLL HYAGEVTYSV TGFLDKNNDL LFRNLKETMC 540
SSKNPIMSQC FDRSELSDKK RPETVATQFK MSLLQLVEIL QSKEPAYVRC IKPNDAKQPG 600
RFDEVLIRHQ VKYLGLLENL RVRRAGFAYR RKYEAFLQRY KSLCPETWPT WAGRPQDGVA 660
VLVRHLGYKP EEYKMGRTKI FIRFPKTLFA TEDALEVRRQ SLATKIQAAW RGFHWRQKFL 720
RVKRSAICIQ SWWRGTLGRR KAAKRKWAAQ TIRRLIRGFV LRHAPRCPEN AFFLDHVRTS 780
FLLNLRRQLP QNVLDTSWPT PPPALREASE LLRELCIKNM VWKYCRSISP EWKQQLQQKA 840
VASEIFKGKK DNYPQSVPRL FISTRLGTDE ISPRVLQALG SEPIQYAVPV VKYDRKGYKP 900
RSRQLLLTPN AVVIVEDAKV KQRIDYANLT GISVSSLSDS LFVLHVQRAD NKQKGDVVLQ 960
SDHVIETLTK TALSANRVNS ININQGSITF AGGPGRDGTI DFTPGSELLI TKAKNGHLAV 1020
VAPRLNSR 1028 
Gene Ontology
 GO:0009925; C:basal plasma membrane; IDA:UniProtKB.
 GO:0005903; C:brush border; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0031941; C:filamentous actin; IDA:UniProtKB.
 GO:0016328; C:lateral plasma membrane; IDA:UniProtKB.
 GO:0045121; C:membrane raft; IDA:UniProtKB.
 GO:0005902; C:microvillus; IDA:UniProtKB.
 GO:0045160; C:myosin I complex; IEA:Compara.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0060171; C:stereocilium membrane; IEA:UniProtKB-SubCell.
 GO:0016461; C:unconventional myosin complex; TAS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0038089; P:positive regulation of cell migration by vascular endothelial growth factor signaling pathway; IMP:UniProtKB.
 GO:0090314; P:positive regulation of protein targeting to membrane; IMP:UniProtKB.
 GO:1900748; P:positive regulation of vascular endothelial growth factor signaling pathway; IMP:UniProtKB.
 GO:0006612; P:protein targeting to membrane; IDA:UniProtKB.
 GO:2000810; P:regulation of tight junction assembly; IMP:UniProtKB. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR010926; Myosin_tail_2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00612; IQ
 PF00063; Myosin_head
 PF06017; Myosin_TH1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.