CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030089
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mthfd1l protein 
Protein Synonyms/Alias
 Protein Mthfd1l 
Gene Name
 Mthfd1l 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
173NKVLNALKPEKDVDGacetylation[1]
188VTDVNLGKLVRGDAPacetylation[1]
371ISRGQTPKAVDVLAKacetylation[1]
515HESTQTDKALYNRLVacetylation[1]
530PLVNGVRKFSEIQLSacetylation[1]
879AQTVYGAKDIELSPEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 977 AA 
Protein Sequence
MSARLPLLLR QLGHQQLPPG PACRLRELCR SGSRSSSSGG GDPEGLRGRR LQDGQAFISH 60
SPGSPEDPGM DSIVRDVIHN SKEVLNLLQE KNPAFKPVLA VIQAGDDHLM QNVNQNLAKE 120
AGLDITHICL PPDSGEDEII DEILKINEDP RVHGLALQIS EDSLCNKVLN ALKPEKDVDG 180
VTDVNLGKLV RGDAPECFVS PLARAAVELI EKSGITLDGK KVLVIGAHGP LEAALQCLFQ 240
RKGSMTMSSP WITPQLQDKL READIVVLGS PKPDEIPAAW IPSGATMLNC FHDFLSGKLR 300
GGSPGVPMNR LIADESVSLL AAALRVQNMV NSGRRWLREQ QHRRWRLHCL KLQPLSPVPS 360
DIEISRGQTP KAVDVLAKEI GLLADEIEIY GKSKAKVRLS LLERLKDQTD GKYVLVAGIT 420
PTPLGEGKST VTIGLVQALT AHLNVNSFAC LRQPSQGPTF GVKGGAAGGG YAQVIPMEEF 480
NLHLTGDIHA ITAANNLLAA AIDTRIFHES TQTDKALYNR LVPLVNGVRK FSEIQLSRLK 540
KLGIHKTDPT ALTEEEVRKF TRLNIDPSTI TWQRVLDTND RFLRKITIGQ GSTEKGYSRQ 600
AQFDIAVASE IMAVLALTDS LADMKERLGR MVVASDKDGQ PVTAEDLGVT GALTVLMKDA 660
IKPNLMQTLE GTPVFVHAGP FANIAHGNSS VLADKIALKL VGEEGFVVTE AGFGADIGME 720
KFFNIKCRAS GLVPNVVVLV ATVRALKMHG GGPSVTAGVP LKKEYTEENI QLVADGCCNL 780
QKQIQIAQLF GVPVVVALNV FKTDTRAEID LVCELAKRAG AFDAVPCYHW SAGGKGSVDL 840
ARAVREAANK RSRFRFLYDV QLPIVAKIRV IAQTVYGAKD IELSPEAQAK IDRYTQQGFG 900
NLPICMAKTH LSLSHEPDKK GVPRDFILPI SDVRASIGAG FIYPLVGMMS TMPGLPTRPC 960
FYDIDLDTET EQVKGLF 977 
Gene Ontology
 GO:0005739; C:mitochondrion; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004329; F:formate-tetrahydrofolate ligase activity; IBA:RefGenome.
 GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IBA:RefGenome.
 GO:0055114; P:oxidation-reduction process; IEA:InterPro. 
Interpro
 IPR000559; Formate_THF_ligase.
 IPR020628; Formate_THF_ligase_CS.
 IPR016040; NAD(P)-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR000672; THF_DH/CycHdrlase.
 IPR020630; THF_DH/CycHdrlase_cat_dom.
 IPR020631; THF_DH/CycHdrlase_NAD-bd_dom. 
Pfam
 PF01268; FTHFS
 PF00763; THF_DHG_CYH
 PF02882; THF_DHG_CYH_C 
SMART
  
PROSITE
 PS00721; FTHFS_1
 PS00722; FTHFS_2 
PRINTS
 PR00085; THFDHDRGNASE.