CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009628
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peptidyl-prolyl cis-trans isomerase A 
Protein Synonyms/Alias
 PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 
Gene Name
 PPIA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Bos taurus (Bovine) 
NCBI Taxa ID
 9913 
Lysine Modification
Position
Peptide
Type
References
28SFELFADKVPKTAENubiquitination[1]
31LFADKVPKTAENFRAubiquitination[1]
44RALSTGEKGFGYKGSubiquitination[1]
49GEKGFGYKGSCFHRIubiquitination[1]
131GKHVVFGKVKEGMNIubiquitination[1]
133HVVFGKVKEGMNIVEubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 
Sequence Annotation
 DOMAIN 7 163 PPIase cyclophilin-type.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylvaline; in Peptidyl-prolyl cis-
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 28 28 N6-acetyllysine; alternate (By
 MOD_RES 44 44 N6-acetyllysine (By similarity).
 MOD_RES 76 76 N6-acetyllysine (By similarity).
 MOD_RES 82 82 N6-acetyllysine (By similarity).
 MOD_RES 93 93 Phosphothreonine (By similarity).
 MOD_RES 125 125 N6-acetyllysine (By similarity).
 MOD_RES 131 131 N6-acetyllysine (By similarity).
 CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
 DISULFID 62 161
 CROSSLNK 28 28 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Acetylation; Complete proteome; Cyclosporin; Cytoplasm; Direct protein sequencing; Disulfide bond; Glycoprotein; Isomerase; Isopeptide bond; Phosphoprotein; Reference proteome; Rotamase; Secreted; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 164 AA 
Protein Sequence
MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF 60
MCQGGDFTRH NGTGGKSIYG EKFDDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE 120
WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQI 164 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0042277; F:peptide binding; IEA:UniProtKB-KW.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; ISS:UniProtKB.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0045069; P:regulation of viral genome replication; ISS:UniProtKB. 
Interpro
 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR024936; Cyclophilin-type_PPIase.
 IPR020892; Cyclophilin-type_PPIase_CS. 
Pfam
 PF00160; Pro_isomerase 
SMART
  
PROSITE
 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 
PRINTS
 PR00153; CSAPPISMRASE.