UniProt Accession

 Q6AZ42_RAT; Q6AZ42 

Genbank Protein ID

 AABR06083426; BC078753; CH474049; CH474049; CH474049 

Genbank Nucleotide ID

 AAH78753.1; EDM14340.1; EDM14341.1; EDM14342.1 

Protein Name

 Gap junction protein 

Protein Synonyms/Alias

  

Gene Name

 Gjb6 

Gene Synonyms/Alias

 rCG_23495 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
116	GEKRNEFKDLEDIKR	ubiquitination	[1]
237	NHPNHALKESKQNEM	ubiquitination	[1]
240	NHALKESKQNEMNEL	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity). 

Sequence Annotation

  

Keyword

 Cell junction; Cell membrane; Complete proteome; Gap junction; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0005922; C:connexon complex; IEA:InterPro.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005921; C:gap junction; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0006915; P:apoptotic process; IEP:RGD.
 GO:0007154; P:cell communication; NAS:RGD.
 GO:0042471; P:ear morphogenesis; IEA:Compara.
 GO:0048839; P:inner ear development; IEP:RGD.
 GO:0008285; P:negative regulation of cell proliferation; IDA:RGD.
 GO:0007605; P:sensory perception of sound; IEA:Compara. 

Interpro

 IPR000500; Connexin.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 

Pfam

 PF00029; Connexin
 PF10582; Connexin_CCC 

SMART

 SM00037; CNX
 SM01089; Connexin_CCC 

PROSITE

 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 

PRINTS

 PR00206; CONNEXIN.