CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004729
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin-2 
Protein Synonyms/Alias
 CDw325; Neural cadherin; N-cadherin; CD325 
Gene Name
 CDH2 
Gene Synonyms/Alias
 CDHN; NCAD 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
448DGLVTVVKPIDFETNubiquitination[1, 2]
536QQNIRYTKLSDPANWubiquitination[1]
756RDKERQAKQLLIDPEubiquitination[2, 3, 4, 5, 6]
772DVRDNILKYDEEGGGubiquitination[2]
802TVEPDAIKPVGIRRMubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity). 
Sequence Annotation
 DOMAIN 160 267 Cadherin 1.
 DOMAIN 268 382 Cadherin 2.
 DOMAIN 383 497 Cadherin 3.
 DOMAIN 498 603 Cadherin 4.
 DOMAIN 604 714 Cadherin 5.
 METAL 262 262 Calcium 1 (By similarity).
 METAL 262 262 Calcium 2 (By similarity).
 METAL 293 293 Calcium 3 (By similarity).
 CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).
 CARBOHYD 273 273 N-linked (GlcNAc...).
 CARBOHYD 325 325 N-linked (GlcNAc...) (Potential).
 CARBOHYD 402 402 N-linked (GlcNAc...).
 CARBOHYD 572 572 N-linked (GlcNAc...).
 CARBOHYD 651 651 N-linked (GlcNAc...) (Potential).
 CARBOHYD 692 692 N-linked (GlcNAc...).  
Keyword
 Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 906 AA 
Protein Sequence
MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF 60
SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK 120
LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL 180
VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV 240
DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300
NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360
GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY 420
RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480
TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP 540
ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 660
FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720
GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780
EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840
KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900
YGGGDD 906 
Gene Ontology
 GO:0016342; C:catenin complex; IDA:BHF-UCL.
 GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
 GO:0005916; C:fascia adherens; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0014704; C:intercalated disc; ISS:BHF-UCL.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0008013; F:beta-catenin binding; TAS:AgBase.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0048514; P:blood vessel morphogenesis; IEA:Compara.
 GO:0016339; P:calcium-dependent cell-cell adhesion; IEA:Compara.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0007157; P:heterophilic cell-cell adhesion; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; IEA:Compara.
 GO:0042692; P:muscle cell differentiation; TAS:Reactome.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0043410; P:positive regulation of MAPK cascade; IEA:Compara.
 GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome.
 GO:0051146; P:striated muscle cell differentiation; IEA:Compara. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR009124; Cadherin/Desmocollin.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR014868; Cadherin_pro_dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C
 PF08758; Cadherin_pro 
SMART
 SM00112; CA
 SM01055; Cadherin_pro 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.
 PR01820; DESMOCOLLIN.