UniProt Accession

 NH2L1_HUMAN; P55769 

Genbank Protein ID

 D50420; AF155235; AF091076; CR456531; Z83840; BC005358; BC019282 

Genbank Nucleotide ID

 BAA23363.1; AAF06959.1; AAC72945.1; CAG30417.1; CAB46207.1; AAH05358.1; AAH19282.1 

Protein Name

 NHP2-like protein 1 

Protein Synonyms/Alias

 High mobility group-like nuclear protein 2 homolog 1; OTK27; SNU13 homolog; hSNU13; U4/U6.U5 tri-snRNP 15.5 kDa protein; NHP2-like protein 1, N-terminally processed 

Gene Name

 NHP2L1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	LADAHLTKKLLDLVQ	ubiquitination	[1]
33	VQQSCNYKQLRKGAN	ubiquitination	[2]
37	CNYKQLRKGANEATK	ubiquitination	[1]
44	KGANEATKTLNRGIS	ubiquitination	[2]
113	IKEGSQLKQQIQSIQ	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 2 2 N-acetylthreonine; in NHP2-like protein  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Polymorphism; Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0031428; C:box C/D snoRNP complex; NAS:BHF-UCL.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0000398; P:mRNA splicing, via spliceosome; TAS:Reactome.
 GO:0042254; P:ribosome biogenesis; IEA:InterPro. 

Interpro

 IPR002415; H/ACA_rnp_Nhp2_euk.
 IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
 IPR018492; Ribosomal_L7Ae/L8/Nhp2.
 IPR004037; Ribosomal_L7Ae_CS. 

Pfam

 PF01248; Ribosomal_L7Ae 

SMART

  

PROSITE

 PS01082; RIBOSOMAL_L7AE 

PRINTS

 PR00881; L7ARS6FAMILY.
 PR00883; NUCLEARHMG.