| Tag | Content |
|---|
| CPLM ID | CPLM-016481 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Smad nuclear-interacting protein 1 |
Protein Synonyms/Alias | |
Gene Name | Snip1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 28 | ALTTVVVKQERLSPE | acetylation | [1] | | 288 | IDHPSCSKQHAVFQY | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity). |
Sequence Annotation | DOMAIN 268 331 FHA.
MOD_RES 18 18 Phosphoserine.
MOD_RES 33 33 Phosphoserine.
MOD_RES 48 48 Phosphoserine (By similarity).
MOD_RES 50 50 Phosphoserine (By similarity).
MOD_RES 381 381 Phosphoserine.
CROSSLNK 28 28 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Coiled coil; Complete proteome; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; RNA-mediated gene silencing; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 383 AA |
Protein Sequence | MKAGKSERER SGRRRHRSGD ALTTVVVKQE RLSPEPVAHR RPDAPAASLS PPAAEPGHSG 60
HRGSRARSPA KKKSKSSGRR SKSPRTKRSQ SPHYPMVKVK QEREDHPRRG REDRQHREPS 120
EQEHRRARNS ERDRHRGHSR QGRSSDERPV SGQDRDRDSQ NLQAQEEERD FHNARRREHR 180
QQNESAGSEA QEVIPRPAGN RSKEVPVKEK PSFELSGALL EDTNTFRGVV IKYSEPPEAR 240
IPKKRWRLYP FKNDEVLPVM YIHRQSAYLL GRHRRIADIP IDHPSCSKQH AVFQYRLVEY 300
TRADGTVGRR VKPYIIDLGS GNGTFLNNKR IEPQRYYELK EKDVLKFGFS SREYVLLHES 360
SDTSELDRKE DEDDEEEEMV SDS 383 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0005634; C:nucleus; IDA:MGI. GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IDA:MGI. GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; ISS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |