| Tag | Content |
|---|
| CPLM ID | CPLM-013935 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mediator of RNA polymerase II transcription subunit 13 |
Protein Synonyms/Alias | Thyroid hormone receptor-associated protein 1; Thyroid hormone receptor-associated protein complex 240 kDa component; Trap240 |
Gene Name | Med13 |
Gene Synonyms/Alias | Kiaa0593; Thrap1; Trap240 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1447 | GNNEAFSKLKLYAQV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). |
Sequence Annotation | MOTIF 1187 1191 LXXLL motif 1.
MOTIF 1278 1282 LXXLL motif 2.
MOD_RES 500 500 Phosphoserine (By similarity).
MOD_RES 504 504 Phosphoserine (By similarity).
MOD_RES 537 537 Phosphoserine (By similarity).
MOD_RES 1028 1028 Phosphoserine (By similarity). |
Keyword | Activator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2171 AA |
Protein Sequence | MSSSFVSNGA SLEDCHCNLF CLADLTGIKW KRYVWQGPTS APILFPVTEE DPILSSFSRC 60
LKADVLGVWR RDQRPGRREL WIFWWGKDPN FADLIHHDLS EEEDGVWENG LSYECRTLLF 120
KAVHNLLERC LMNRNFVRIG KWFVKPYEKD EKPINKSEHL SCSFTFFLHG DSNVCTSVEI 180
NQHQPVYLLS EEHVTLAQQS NSPFQVILSP FGLNGTLTGQ AFKMSDSATK KLIGEWKQFY 240
PISCGLKEMS EEKQDDMDWE DDSLAAVEVL VAGVRMIYPA CFVLVPQSDI PAPSSVGASH 300
CSASCLGIHQ VPASTRDPAM SSVTLTPPTS PEEVQTVDPQ SAQKWVKFSS VSDGFSTDST 360
SHHGGKIPRK LANHVVDRVW QECNMNRLQN KRKYSATSSG LCEEETADKI GCWDFVEATQ 420
RTSCSCLRHK SLKTRNTGQQ GQAPSLGQQQ QVLPKHKTNE KQDKSEKPQK RPLTPFHHRV 480
SVSDEIGMDT DSASQRLVIS AADSQVRFSN IRTNDVAKTP QMHGTELANS PQPPPLSPHP 540
CDVVDEGVTK TPSTPQSQHF YQMPTPDPLV PTKPMEDRID SLSQSFPPPF QEAVEPTVYV 600
GTAVSLEEDE ANVAWKYYKV PKKKDVEFLP PQLPNDKFKD DPVGPFGQES VTSVTELMVQ 660
CKKPLKVSDE IVQQYQIKNQ YLSAIASDTE QEPKIDPYAF VEGDEEFIFT DKKDRQNSER 720
EAGKKHKVED GTSAVTVLSH EEDAMSLFSP SKQDAPRPTN HARPPSTSLI YDSDLAVSYT 780
DLDNLFNSDE DELTPGSKKS ASGSDDKASS KESKTGNLDP LSCISTADLH KMYPTPPSLE 840
QHIMGFSPMN MNNKEYGSVD TAPGGTVLEG NSSSVGTQFR IEVEEGFCSP KPSEIKDFSY 900
VYKPENCQVL VGCSMFAPLK TLPSHCLPPI KLPEECVYRQ SWTVGKLDLL PSGPSMPFIK 960
EGDGSNLDQD YGPAYTPQTH ASFGMPPSSA PPSNGGAGIL PSPSTPRFPT PRTPRTPRTP 1020
RGAGGPASAQ GSVKYENSDL YSPASTPSTC RPLNSVEPAT VPSIPEAHSL YVNLILSESV 1080
MNLFKDCNFD SCCICVCNMN IKGADVGVYI PDPTQEAQYR CTCGFSAVMN RKFGNNSGLF 1140
LEDELDIIGR NTDCGKEAEK RFEALRASSV ENVNGGLKES EKVPDELILL LQDQCTNLFS 1200
PFGAADQDPF PKVGISSNWV RVEERDCCSD CCLALEHGRQ FMDNMSGGKV DEALVRSSCL 1260
HPWAKQNDAS VQCSQDILRM LLSLQPVLQD AIQKKRTVRP WGVQGPLTWQ QFHKMAGRGS 1320
YGTDESPEPL PIPTFLLGYD YDFLVLSPFA LPYWEKLMLE PYGSQRDIAY VVLCPENEAL 1380
LNGARSFFRD LTAIYESCRL GQHRPISRLL TDGIMKVGAT ASKKLSEKFV TEWFSQAADG 1440
NNEAFSKLKL YAQVCRYDLG PYLASQPLDS SLLSQPNLVA PPNQSLVTAP QMTNTGNANA 1500
PSATLASAAS STMTMTSGVP ISTSVATANS TLTTTSSSSS SSLSSGVSSN KLPSFPPFGS 1560
MNTSGTGSMS AQASTVQSGQ LGGQQSSSLQ AAGISGESAS LPTQPHPDVS ESTMDRDKVG 1620
IPTDGDSHAI TYPPAIVVYI IDPFTYENKD ESTNSSNVWT LGLLRCFLEM VQTLPPHIKS 1680
TVSVQIVPCQ YLLQPVKHDD RQIYSQHLKS LAFSVFTQCR RPLPTSTNVK TLTGFGPGLA 1740
METALKSPDR PECIRLYTPP FILAPVKDKQ TELGETFGEA GQKYNVLFVG YCLSHDQRWI 1800
LASCTDLYGE LLETCIINID VPNRARRKKG SARRFGLQKL WEWCLGLVQM SSLPWRVVIG 1860
RLGRIGHGEL KDWSCLLSRR NLQSLSKRLK DMCRMCGISA ADSPSILSAC LVAMEPQGSF 1920
VIMPDSVSTG SVFGRSTTLN MQTPQLNTPQ DTSCTHILVF PTSASVQVAS ATYTTENLDL 1980
AFNPNNDGAD GMGIFDLLDT GDDLDPDIIN ILPASPTASP VHSPGSHYPH GGDAGKGQGT 2040
DRLLSTESHD EVTNILQQPL ALGYFVSTAK AGPLPDWFWS ACPQAQYQCP LFLKASLHLH 2100
VPSVQSDELL HSKHSHPLDS NQTSDVLRFV LEQYNALSWL TCDPAVQDRR SCLPVHFVVL 2160
NQLYNFIMNM L 2171 |
Gene Ontology | GO:0016592; C:mediator complex; IDA:MGI. GO:0004872; F:receptor activity; IEA:Compara. GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:Compara. GO:0003713; F:transcription coactivator activity; IEA:Compara. GO:0030521; P:androgen receptor signaling pathway; IEA:Compara. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:Compara. |
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PROSITE | |
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