CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014952
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Keratin, type II cytoskeletal 73 
Protein Synonyms/Alias
 Cytokeratin-73; CK-73; Keratin-73; K73; Type II inner root sheath-specific keratin-K6irs3; Type-II keratin Kb36 
Gene Name
 Krt73 
Gene Synonyms/Alias
 Kb36 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
264DALDGEIKFLKCLYEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). 
Sequence Annotation
 REGION 1 130 Head.
 REGION 131 440 Rod.
 REGION 131 166 Coil 1A.
 REGION 167 185 Linker 1.
 REGION 186 277 Coil 1B.
 REGION 278 301 Linker 12.
 REGION 302 440 Coil 2.
 REGION 441 539 Tail.  
Keyword
 Coiled coil; Complete proteome; Direct protein sequencing; Intermediate filament; Keratin; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 553 AA 
Protein Sequence
MNRQFTCKSG AANRGFSGCS AVLSGGSASS YRAGGKGLGG GFSSRSLYSL RSPRSISFNV 60
ASGSGRTGGY GFGRNRASGF AGSMFGGGAL GPSNPSLCLP GGIHQVTVNK SLLAPLNVEL 120
DPEIQKVRAQ EREQIKALNN KFASFIDKVR FLEQQNQVLQ TKWELLQQLD LSNCRRNLEP 180
VYEAHISSLQ KQLDSLSGDR VRLDSELRGM RDAVEDCKKR YEEEINKRTT AENEFVVLKK 240
DVDAAYMSKV ELQAKVDALD GEIKFLKCLY EGEITQMQSH ISDTSVVLSM DNNRNLDLDS 300
IIAEVRAQYE DIALKSKAEA EMVYQTKFQE LQLAAGRHGD DLKHTRNEIS ELTRLIQRLR 360
SEIESVKKQC SNLETAIADA EQRGDCALKD AQAKLDDLER ALHQAKEELA RMLREHQELM 420
SMKLALDIEI ATYRKLLEGE ECRMSGEHTN AVSISVISSS TTGAVGAGTS FGFSNPSTYG 480
YRPSSVAGGY GILSGGCVTG SGNCSPRGDT KTRLGSASEF KEVSGKTLAL GSPSKKTMRA 540
DRQSSISVQL WFS 553 
Gene Ontology
 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR003054; Keratin_II. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01276; TYPE2KERATIN.