UniProt Accession

 GCR_HUMAN; P04150; A0ZXF9; B0LPG8; D3DQF4; P04151; Q53EP5; Q6N0A4 

Genbank Protein ID

 X03225; X03348; U80946; U78506; U78507; U78508; U78509; U78510; U78511; U78512; U80947; U78506; U78507; U78508; U78509; U78510; U78511; U78512; HQ205546; HQ205547; HQ205548; HQ205549; HQ205550; HQ205551; HQ205552; HQ205553; HQ205554; HQ205555; HQ205556; HQ205557; HQ205558; HQ205559; HQ205560; HQ205561; HQ205562; HQ205563; HQ205564; HQ205565; HQ205566; HQ205567; HQ205568; HQ205569; HQ205570; HQ205571; HQ205572; HQ205573; HQ205574; HQ205575; HQ205576; HQ205577; HQ205578; HQ205579; HQ205580; HQ205581; HQ205582; HQ205583; HQ205584; HQ205585; AM183262; U01351; AK223594; BX640610; AY436590; EU332858; AC005601; AC004782; AC091925; CH471062; CH471062; BC015610; M69104; AH002750; S68378 

Genbank Nucleotide ID

 CAA26976.1; CAA27054.1; AAB64353.1; AAB64353.1; AAB64353.1; AAB64353.1; AAB64353.1; AAB64353.1; AAB64353.1; AAB64353.1; AAB64354.1; AAB64354.1; AAB64354.1; AAB64354.1; AAB64354.1; AAB64354.1; AAB64354.1; AAB64354.1; ADP91135.1; ADP91138.1; ADP91141.1; ADP91144.1; ADP91147.1; ADP91150.1; ADP91153.1; ADP91156.1; ADP91159.1; ADP91162.1; ADP91165.1; ADP91168.1; ADP91171.1; ADP91174.1; ADP91177.1; ADP91180.1; ADP91183.1; ADP91186.1; ADP91189.1; ADP91192.1; ADP91195.1; ADP91198.1; ADP91201.1; ADP91204.1; ADP91207.1; ADP91210.1; ADP91213.1; ADP91216.1; ADP91219.1; ADP91222.1; ADP91225.1; ADP91228.1; ADP91231.1; ADP91234.1; ADP91237.1; ADP91240.1; ADP91243.1; ADP91246.1; ADP91249.1; ADP91252.1; CAJ65924.1; AAA16603.1; BAD97314.1; CAE45716.1; AAQ97180.1; ABY87547.1; AAC34207.1; EAW61872.1; EAW61873.1; AAH15610.1; AAA88049.1; AAA53151.1; AAB20466.1 

Protein Name

 Glucocorticoid receptor 

Protein Synonyms/Alias

 GR; Nuclear receptor subfamily 3 group C member 1 

Gene Name

 NR3C1 

Gene Synonyms/Alias

 GRL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
277	NVTLPQVKTEKEDFI	sumoylation	[1, 2]
293	LCTPGVIKQEKLGTV	sumoylation	[1, 2]
494	NLEARKTKKKIKGIQ	acetylation	[3]
495	LEARKTKKKIKGIQQ	acetylation	[3]
681	SVPKDGLKSQELFDE	ubiquitination	[4]
703	ELGKAIVKREGNSSQ	sumoylation	[1]

Reference

 [1] Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor.
 Tian S, Poukka H, Palvimo JJ, Jänne OA.
 Biochem J. 2002 Nov 1;367(Pt 3):907-11. [PMID: 12144530]
 [2] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634]
 [3] Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression.
 Ito K, Yamamura S, Essilfie-Quaye S, Cosio B, Ito M, Barnes PJ, Adcock IM.
 J Exp Med. 2006 Jan 23;203(1):7-13. [PMID: 16380507]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. 

Sequence Annotation

 DNA_BIND 421 486 Nuclear receptor.
 ZN_FING 421 441 NR C4-type.
 ZN_FING 457 481 NR C4-type.
 REGION 1 420 Modulating.
 REGION 487 527 Hinge.
 REGION 528 777 Steroid-binding.
 MOD_RES 113 113 Phosphoserine (By similarity).
 MOD_RES 134 134 Phosphoserine.
 MOD_RES 141 141 Phosphoserine (By similarity).
 MOD_RES 203 203 Phosphoserine.
 MOD_RES 211 211 Phosphoserine.
 MOD_RES 226 226 Phosphoserine.
 MOD_RES 267 267 Phosphoserine.
 CROSSLNK 277 277 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 293 293 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 419 419 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Alternative initiation; Alternative splicing; Chromatin regulator; Complete proteome; Cytoplasm; Disease mutation; DNA-binding; Isopeptide bond; Lipid-binding; Metal-binding; Mitochondrion; Nucleus; Phosphoprotein; Polymorphism; Pseudohermaphroditism; Receptor; Reference proteome; Steroid-binding; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 777 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005759; C:mitochondrial matrix; TAS:ProtInc.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004883; F:glucocorticoid receptor activity; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030325; P:adrenal gland development; IEA:Compara.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0008211; P:glucocorticoid metabolic process; IEA:Compara.
 GO:0060603; P:mammary gland duct morphogenesis; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0031946; P:regulation of glucocorticoid biosynthetic process; IEA:Compara.
 GO:0006111; P:regulation of gluconeogenesis; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 

Interpro

 IPR001409; Glcrtcd_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF02155; GCR
 PF00104; Hormone_recep
 PF00105; zf-C4 

SMART

 SM00430; HOLI
 SM00399; ZnF_C4 

PROSITE

 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 

PRINTS

 PR00528; GLCORTICOIDR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.