UniProt Accession

 H7C1V0_HUMAN; H7C1V0 

Genbank Protein ID

 AC068580 

Genbank Nucleotide ID

  

Protein Name

 Cathepsin D light chain 

Protein Synonyms/Alias

  

Gene Name

 CTSD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
90	DEVRELQKAIGAVPL	ubiquitination	[1]
108	EYMIPCEKVSTLPAI	ubiquitination	[1]
118	TLPAITLKLGGKGYK	ubiquitination	[1]
125	KLGGKGYKLSPEDYT	ubiquitination	[1, 2]
134	SPEDYTLKVSQAGKT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Aspartyl protease; Complete proteome; Hydrolase; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR001461; Peptidase_A1.
 IPR021109; Peptidase_aspartic.
 IPR001969; Peptidase_aspartic_AS. 

Pfam

 PF00026; Asp 

SMART

  

PROSITE

 PS00141; ASP_PROTEASE 

PRINTS

 PR00792; PEPSIN.