CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021104
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Striatin-3 
Protein Synonyms/Alias
 Cell cycle autoantigen SG2NA; S/G2 antigen 
Gene Name
 Strn3 
Gene Synonyms/Alias
 Gs2na; Sg2na 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
173QNSQLTWKQGRQLLRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity). 
Sequence Annotation
 REPEAT 477 516 WD 1.
 REPEAT 530 569 WD 2.
 REPEAT 583 622 WD 3.
 REPEAT 678 717 WD 4.
 REPEAT 720 759 WD 5.
 REPEAT 766 795 WD 6.
 REGION 71 79 Caveolin-binding (Potential).
 REGION 166 183 Calmodulin-binding (Potential).
 MOD_RES 229 229 Phosphoserine.
 MOD_RES 257 257 Phosphoserine.  
Keyword
 Calmodulin-binding; Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 796 AA 
Protein Sequence
MDELAGGGGG GQGMAAPPRP QQGPGGNLSL PPGANGAPGG GGPPAAEAAG PPAGPELSRP 60
QQYTIPGILH YIQHEWARFE MERAHWEVER AELQARIAFL QGERKGQENL KKDLVRRIKM 120
LEYALKQERA KYHKLKYGTE LNQGDLKMPT FESEETKDVE APPAPQNSQL TWKQGRQLLR 180
QYLQEVGYTD TILDVRSQRV RSLLGLSNSE PNGSVEAKNL EQILNGGESP KQKGQEIKRP 240
PGDVLETFNF LENADDSDEE ENDMIEGIPE GKDKLRIHKH KIGNEGLAAD LTDDPDTEEA 300
LKEFDFLVTA EDGEGAGEAR SSGDGTEWDK DDLSPTAEVW DVDQGLISKL KEQYKKERKG 360
KKGVKRVNRT NLCDMITDLG DDELPHIPSG IINQSRSAST RMADHEGARA EEAEPITFPS 420
GGGKSFIMGS DDVLLSVLGL GDLADLTVTN DADYSYDLPA NKDAFRKTWN PKYTLRSHFD 480
GVRALAFHPV EPVLVTASED HTLKLWNLQK TVPAKKSASL DVEPIYTFRA HIGPVLSLAI 540
SSNGEQCFSG GIDATIQWWN MPSPNVDPYD TYESNVLAGT LVAHTDAVWG LAYSGIKNQL 600
LSCSADGTIR LWNPQEKLPC VCTYNGDKEH GIPTSVDFIG CDPAHMVTSF NTGSAVIYDL 660
ETSQSLVMLS SQVDSGLQSS NHINRVVSHP TLPVTITAHE DRHIKFFDNK TGKMIHSMVA 720
HLDAVTSLAV DPNGIYLMSG SHDCSIRLWN LDSKTCVQEI TAHRKKLDES IYDVAFHPSK 780
AYIASAGADA LAKVFV 796 
Gene Ontology
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0000159; C:protein phosphatase type 2A complex; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR013258; Striatin_N.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08232; Striatin
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.