UniProt Accession

 KRA55_HUMAN; Q701N2; A8MWN2 

Genbank Protein ID

 AB126074; AJ628247; AP006285 

Genbank Nucleotide ID

 BAD20201.1; CAF31639.1 

Protein Name

 Keratin-associated protein 5-5 

Protein Synonyms/Alias

 Keratin-associated protein 5-11; Keratin-associated protein 5.11; Keratin-associated protein 5.5; Ultrahigh sulfur keratin-associated protein 5.5 

Gene Name

 KRTAP5-5 

Gene Synonyms/Alias

 KAP5-11; KAP5.5; KRTAP5-11; KRTAP5.11; KRTAP5.5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
86	CSCSSCGKGGCGSCG	ubiquitination	[1]
136	CGSCGGSKGGCGSCG	ubiquitination	[1]
146	CGSCGGSKGGCGSYG	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. 

Sequence Annotation

 REPEAT 62 65 1.
 REPEAT 68 71 2.
 REPEAT 74 77 3.
 REPEAT 159 162 4.
 REPEAT 178 181 5.
 REPEAT 188 191 6.
 REPEAT 198 201 7.
 REPEAT 227 230 8.
 REGION 62 230 8 X 4 AA repeats of C-C-X-P.  

Keyword

 Complete proteome; Keratin; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0045095; C:keratin filament; IEA:InterPro. 

Interpro

 IPR002494; Keratin-assoc. 

Pfam

  

SMART

  

PROSITE

  

PRINTS