CPLM-024127

Genbank Nucleotide ID

Heterogeneous nuclear ribonucleoproteins C1/C2

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
8	MASNVTNKTDPRSMN	acetylation	[1]
8	MASNVTNKTDPRSMN	succinylation	[1]
29	NLNTLVVKKSDVEAI	ubiquitination	[2]
39	DVEAIFSKYGKIVGC	acetylation	[3]
39	DVEAIFSKYGKIVGC	ubiquitination	[2]
89	INLAAEPKVNRGKAG	ubiquitination	[2]
170	GNTSRRGKSGFNSKS	acetylation	[1]
176	GKSGFNSKSGQRGSS	acetylation	[1]
176	GKSGFNSKSGQRGSS	succinylation	[1]
190	SSKSGKLKGDDLQAI	ubiquitination	[2]
198	GDDLQAIKKELTQIK	acetylation	[4]
199	DDLQAIKKELTQIKQ	ubiquitination	[2]
207	ELTQIKQKVDSLLES	acetylation	[1]
207	ELTQIKQKVDSLLES	ubiquitination	[2]
217	SLLESLEKIEKEQSK	acetylation	[3]
217	SLLESLEKIEKEQSK	ubiquitination	[2]
224	KIEKEQSKQADLSFS	ubiquitination	[2]
237	FSSPVEMKNEKSEEE	acetylation	[3]
237	FSSPVEMKNEKSEEE	ubiquitination	[2]
240	PVEMKNEKSEEEQSS	acetylation	[3]

[1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[4] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]

Functional Description

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (By similarity).

DOMAIN 16 87 RRM.
MOTIF 155 161 Nuclear localization signal (Potential).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 39 39 N6-acetyllysine (By similarity).
MOD_RES 107 107 Phosphoserine (By similarity).
MOD_RES 113 113 Phosphoserine (By similarity).
MOD_RES 115 115 Phosphoserine (By similarity).
MOD_RES 120 120 Phosphoserine (By similarity).
MOD_RES 121 121 Phosphoserine (By similarity).
MOD_RES 138 138 Phosphoserine (By similarity).
MOD_RES 162 162 Phosphoserine (By similarity).
MOD_RES 170 170 N6-acetyllysine (By similarity).
MOD_RES 217 217 N6-acetyllysine (By similarity).
MOD_RES 232 232 Phosphoserine.
MOD_RES 241 241 Phosphoserine.
MOD_RES 246 246 Phosphoserine (By similarity).
MOD_RES 247 247 Phosphoserine (By similarity).
MOD_RES 249 249 Phosphoserine.
MOD_RES 268 268 Phosphoserine.
MOD_RES 306 306 Phosphoserine (By similarity).
MOD_RES 313 313 Phosphoserine (By similarity).
CROSSLNK 258 258 Glycyl lysine isopeptide (Lys-Gly)

Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Isopeptide bond; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
GO:0045120; C:pronucleus; IDA:MGI.
GO:0005681; C:spliceosomal complex; ISS:HGNC.
GO:0003729; F:mRNA binding; IDA:MGI.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.

IPR017347; hnRNP_C_Raly.
IPR012677; Nucleotide-bd_a/b_plait.
IPR000504; RRM_dom.