UniProt Accession

 SMD1_HUMAN; P62314; B5BTZ1; P13641 

Genbank Protein ID

 J03798; L36188; L36182; L36186; L36187; CR542239; AB451227; AB451350; CH471088; BC001721; BC072427 

Genbank Nucleotide ID

 AAA36620.1; AAA85339.1; AAA85339.1; AAA85339.1; AAA85339.1; CAG47035.1; BAG70041.1; BAG70164.1; EAX01130.1; AAH01721.1; AAH72427.1 

Protein Name

 Small nuclear ribonucleoprotein Sm D1 

Protein Synonyms/Alias

 Sm-D1; Sm-D autoantigen; snRNP core protein D1 

Gene Name

 SNRPD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	KAVKMTLKNREPVQL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 119 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0030532; C:small nuclear ribonucleoprotein complex; TAS:ProtInc.
 GO:0005689; C:U12-type spliceosomal complex; IDA:UniProtKB.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0034660; P:ncRNA metabolic process; TAS:Reactome.
 GO:0000245; P:spliceosomal complex assembly; TAS:ProtInc.
 GO:0000387; P:spliceosomal snRNP assembly; TAS:Reactome. 

Interpro

 IPR027141; LSm4/Sm_D1/D3.
 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS