UniProt Accession

 FABG_ECOLI; P0AEK2; P25716; P78221; Q47202 

Genbank Protein ID

 M84991; U00096; AP009048; M87040 

Genbank Nucleotide ID

 AAA23739.1; AAC74177.1; BAA35901.1; AAA23743.1 

Protein Name

 3-oxoacyl-[acyl-carrier-protein] reductase FabG 

Protein Synonyms/Alias

 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase 

Gene Name

 fabG 

Gene Synonyms/Alias

 b1093; JW1079 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
54	DYLGANGKGLMLNVT	acetylation	[1]
72	SIESVLEKIRAEFGE	acetylation	[1]
99	DNLLMRMKDEEWNDI	acetylation	[1]
163	AGLIGFSKSLAREVA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the NADPH-dependent reduction of beta- ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. 

Sequence Annotation

 NP_BIND 12 15 NADP.
 NP_BIND 59 60 NADP.
 NP_BIND 151 155 NADP.
 ACT_SITE 151 151 Proton acceptor (By similarity).
 METAL 50 50 Calcium 1; via carbonyl oxygen; shared
 METAL 53 53 Calcium 1; via carbonyl oxygen; shared
 METAL 145 145 Calcium 2.
 METAL 233 233 Calcium 3; shared with dimeric partner.
 METAL 234 234 Calcium 3; via carbonyl oxygen; shared
 BINDING 37 37 NADP.
 BINDING 86 86 NADP; via carbonyl oxygen.
 BINDING 138 138 Substrate (By similarity).
 BINDING 184 184 NADP; via amide nitrogen and carbonyl  

Keyword

 3D-structure; Calcium; Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Metal-binding; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0004316; F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; IMP:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IDA:UniProtKB.
 GO:0009102; P:biotin biosynthetic process; IMP:EcoCyc.
 GO:0030497; P:fatty acid elongation; IMP:UniProtKB. 

Interpro

 IPR011284; 3oxo_ACP_reduc.
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.