UniProt Accession

 SOMA_HUMAN; P01241; A6NEF6; Q14405; Q16631; Q5EB53; Q9HBZ1; Q9UMJ7; Q9UNL5 

Genbank Protein ID

 V00519; V00520; M13438; J03071; AF185611; AF110644; EU421712; AC127029; CH471109; BC062475; BC075012; BC075013; BC090045; CD106566; M14398 

Genbank Nucleotide ID

 CAA23778.1; CAA23779.1; AAA98618.1; AAA52549.1; AAG09699.1; AAD48584.1; ABZ88713.1; EAW94233.1; AAH62475.1; AAH75012.1; AAH75013.1; AAH90045.1; AAA52554.1 

Protein Name

 Somatotropin 

Protein Synonyms/Alias

 Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone 

Gene Name

 GH1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
64	FEEAYIPKEQKYSFL	acetylation	[1]
96	NREETQQKSNLELLR	acetylation	[1]
96	NREETQQKSNLELLR	methylation	[2]
141	SNVYDLLKDLEEGIQ	acetylation	[1]
166	PRTGQIFKQTYSKFD	acetylation	[1]
194	GLLYCFRKDMDKVET	acetylation	[1]
198	CFRKDMDKVETFLRI	acetylation	[1]

Reference

 [1] Determination of the effect of acetylation of specific lysine residues in human growth hormone on its affinity for somatogenic receptors by an affinity selection technique.
 Teh LC, Chapman GE.
 Biochem Biophys Res Commun. 1988 Jan 15;150(1):391-8. [PMID: 3122756]
 [2] Mass spectrometrical analysis of recombinant human growth hormone (Genotropin(R)) reveals amino acid substitutions in 2% of the expressed protein.
 Hepner F, Cszasar E, Roitinger E, Lubec G.
 Proteome Sci. 2005 Feb 11;3(1):1. [PMID: 15707495] 

Functional Description

 Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. 

Sequence Annotation

 METAL 44 44 Zinc (By similarity).
 METAL 200 200 Zinc (By similarity).
 MOD_RES 132 132 Phosphoserine.
 MOD_RES 163 163 Deamidated glutamine; by deterioration.
 MOD_RES 176 176 Phosphoserine.
 MOD_RES 178 178 Deamidated asparagine; by deterioration.
 DISULFID 79 191
 DISULFID 208 215  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Dwarfism; Hormone; Metal-binding; Pharmaceutical; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0005131; F:growth hormone receptor binding; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0070977; P:bone maturation; IDA:BHF-UCL.
 GO:0015758; P:glucose transport; IDA:MGI.
 GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.
 GO:0010535; P:positive regulation of activation of JAK2 kinase activity; IDA:BHF-UCL.
 GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IDA:BHF-UCL.
 GO:0043406; P:positive regulation of MAP kinase activity; TAS:BHF-UCL.
 GO:0040018; P:positive regulation of multicellular organism growth; IDA:BHF-UCL.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IDA:BHF-UCL.
 GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IDA:BHF-UCL.
 GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IDA:BHF-UCL.
 GO:0032355; P:response to estradiol stimulus; IDA:BHF-UCL. 

Interpro

 IPR009079; 4_helix_cytokine-like_core.
 IPR012351; 4_helix_cytokine_core.
 IPR001400; Somatotropin.
 IPR018116; Somatotropin_CS. 

Pfam

 PF00103; Hormone_1 

SMART

  

PROSITE

 PS00266; SOMATOTROPIN_1
 PS00338; SOMATOTROPIN_2 

PRINTS

 PR00836; SOMATOTROPIN.