CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022334
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centlein 
Protein Synonyms/Alias
 Centrosomal protein 
Gene Name
 CNTLN 
Gene Synonyms/Alias
 C9orf101; C9orf39 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
329MDITLVRKELQELQNubiquitination[1]
1158EDLKFRQKVNLESNKacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 MOD_RES 5 5 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1405 AA 
Protein Sequence
MAARSPPSPH PSPPARQLGP RSPRVGRGAE VHAMRSEASG FAGAAREVVA DESDKIWVGE 60
EGSGGRRGPG GAAPAHAPLL SAPMGSRRLE GISVEEAMVT RTQLLEEELS SLKEELALCQ 120
ADKEFVWSLW KRLQVTNPDL TQVVSLVVER EKQKSEAKDR KVLEILQVKD AKIQEFEQRE 180
SVLKQEINDL VKRKIAVDEE NAFLRKEFSD LEKKFKDKSQ EIKDTKECVQ NKEEQNRLVI 240
KNLEEENKKL STRCTDLLND LEKLRKQEAH LRKEKYSTDA KIKTFEDNLI EARKEVEVSQ 300
SKYNALSLQL SNKQTELIQK DMDITLVRKE LQELQNLYKQ NSTHTAQQAE LIQQLQVLNM 360
DTQKVLRNQE DVHTAESISY QKLYNELHIC FETTKSNEAM LRQSVTNLQD QLLQKEQENA 420
KLKEKLQESQ GAPLPLPQES DPDYSAQVPH RPSLSSLETL MVSQKSEIEY LQEKLKIANE 480
KLSENISANK GFSRKSIMTS AEGKHKEPPV KRSRSLSPKS SFTDSEELQK LRKAERKIEN 540
LEKALQLKSQ ENDELRDAHE KRKERLQMLQ TNYRAVKEQL KQWEEGSGMT EIRKIKRADP 600
QQLRQEDSDA VWNELAYFKR ENQELMIQKM NLEEELDELK VHISIDKAAI QELNRCVAER 660
REEQLFRSGE DDEVKRSTPE KNGKEMLEQT LQKVTELENR LKSFEKRSRK LKEGNKKLMK 720
ENDFLKSLLK QQQEDTETRE KELEQIIKGS KDVEKENTEL QVKISELETE VTSLRRQVAE 780
ANALRNENEE LINPMEKSHQ SADRAKSEMA TMKVRSGRYD CKTTMTKVKF KAAKKNCSVG 840
RHHTVLNHSI KVMSNVFENL SKDGWEDVSE SSSDSEAQTS QTLGTIIVET SQKISPTEDG 900
KDQKESDPTE DSQTQGKEIV QTYLNIDGKT PKDYFHDKNA KKPTFQKKNC KMQKSSHTAV 960
PTRVNREKYK NITAQKSSSN IILLRERIIS LQQQNSVLQN AKKTAELSVK EYKEVNEKLL 1020
HQQQVSDQRF QTSRQTIKKL NLDLAGLRKE KEDLLKKLES SSEITSLAEE NSQVTFPRIQ 1080
VTSLSPSRSM DLEMKQLQYK LKNATNELTK QSSNVKTLKF ELLAKEEHIK EMHEKISRME 1140
RDITMKRHLI EDLKFRQKVN LESNKSFSEM LQNLDKKVKT LTEECSNKKV SIDSLKQRLN 1200
VAVKEKSQYE QMYQKSKEEL EKKDLKLTLL VSRISETESA MAEIETAASK QLQELALQSE 1260
QVLEGAQKTL LLANEKVEEF TTFVKALAKE LQNDVHVVRR QIRELKKMKK NRDACKTSTH 1320
KAQTLAASIL NISRSDLEEI LDTEDQVEIE KTKIDAENDK EWMLYIQKLL EGQSLTLSPR 1380
LKCNGAIMAH QNLRLPDSSS SASAS 1405 
Gene Ontology
 GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
 GO:0000160; P:phosphorelay signal transduction system; IEA:GOC.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC. 
Interpro
 IPR003661; Sig_transdc_His_kin_sub1_dim/P. 
Pfam
  
SMART
 SM00388; HisKA 
PROSITE
  
PRINTS