| Tag | Content |
|---|
| CPLM ID | CPLM-010520 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | U7 snRNA-associated Sm-like protein LSm11 |
Protein Synonyms/Alias | |
Gene Name | LSM11 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 120 | LRRLMVAKEEGDGAA | ubiquitination | [1] | | 242 | SKKEADSKSAVEDST | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA. |
Sequence Annotation | REGION 171 204 SM 1.
REGION 343 356 SM 2.
MOD_RES 21 21 Phosphoserine. |
Keyword | Complete proteome; Direct protein sequencing; mRNA processing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 360 AA |
Protein Sequence | MEERERGARS AGAGSPARPP SPRLDVSSDS FDPLLALYAP RLPPIPYPNA PCFNNVAEYE 60
SFLRTGVRGG GRGRGRARGA AAGSGVPAAP GPSGRTRRRP DAPAPDPERI QRLRRLMVAK 120
EEGDGAAGAG RRGPGRSRKA PRNVLTRMPL HEGSPLGELH RCIREGVKVN VHIRTFKGLR 180
GVCTGFLVAF DKFWNMALTD VDETYRKPVL GKAYERDSSL TLTRLFDRLK LQDSSKKEAD 240
SKSAVEDSTL SRYSQTSTWK LASVWGRADT GRGSHKRSRS VPSSLQASAR EESRSELSGR 300
TTRTDGSSVG GTFSRATTLS RGQSRKKKRK PKVDYQQVFT RHINQIFIRG ENVLLVHLAQ 360 |
Gene Ontology | GO:0071204; C:histone pre-mRNA 3'end processing complex; ISS:UniProtKB. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0005683; C:U7 snRNP; IDA:UniProtKB. GO:0071209; F:U7 snRNA binding; IDA:UniProtKB. GO:0006398; P:histone mRNA 3'-end processing; ISS:UniProtKB. GO:0000084; P:S phase of mitotic cell cycle; IMP:UniProtKB. GO:0006369; P:termination of RNA polymerase II transcription; TAS:Reactome. |
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SMART | |
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PRINTS | |