CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023643
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium/hydrogen exchanger 8 
Protein Synonyms/Alias
 Na(+)/H(+) exchanger 8; NHE-8; Solute carrier family 9 member 8 
Gene Name
 SLC9A8 
Gene Synonyms/Alias
 KIAA0939; NHE8 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
572HHGRIQMKTLTNKWYubiquitination[1]
577QMKTLTNKWYEEVRQubiquitination[1, 2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. 
Sequence Annotation
 MOD_RES 571 571 Phosphoserine.
 MOD_RES 573 573 Phosphoserine.  
Keyword
 Alternative splicing; Antiport; Complete proteome; Golgi apparatus; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 581 AA 
Protein Sequence
MGEKMAEEER FPNTTHEGFN VTLHTTLVVT TKLVLPTPGK PILPVQTGEQ AQQEEQSSGM 60
TIFFSLLVLA ICIILVHLLI RYRLHFLPES VAVVSLGILM GAVIKIIEFK KLANWKEEEM 120
FRPNMFFLLL LPPIIFESGY SLHKGNFFQN IGSITLFAVF GTAISAFVVG GGIYFLGQGF 180
FFVCVCVFVC FILQADVISK LNMTDSFAFG SLISAVDPVA TIAIFNALHV DPVLNMLVFG 240
ESILNDAVSI VLTNTAEGLT RKNMSDVSGW QTFLQALDYF LKMFFGSAAL GTLTGLISAL 300
VLKHIDLRKT PSLEFGMMII FAYLPYGLAE GISLSGIMAI LFSGIVMSHY THHNLSPVTQ 360
ILMQQTLRTV AFLCETCVFA FLGLSIFSFP HKFEISFVIW CIVLVLFGRA VNIFPLSYLL 420
NFFRDHKITP KMMFIMWFSG LRGAIPYALS LHLDLEPMEK RQLIGTTTIV IVLFTILLLG 480
GSTMPLIRLM DIEDAKAHRR NKKDVNLSKT EKMGNTVESE HLSELTEEEY EAHYIRRQDL 540
KGFVWLDAKY LNPFFTRRLT QEDLHHGRIQ MKTLTNKWYE EVRQGPSGSE DDEQELL 597 
Gene Ontology
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015386; F:potassium:hydrogen antiporter activity; IEA:Compara.
 GO:0015385; F:sodium:hydrogen antiporter activity; IEA:Compara.
 GO:0006811; P:ion transport; TAS:Reactome.
 GO:0051453; P:regulation of intracellular pH; IEA:Compara.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 
Interpro
 IPR006153; Cation/H_exchanger.
 IPR018422; Cation/H_exchanger_CPA1.
 IPR018409; Na/H_exchanger_8_eu.
 IPR004709; NaH_exchanger. 
Pfam
 PF00999; Na_H_Exchanger 
SMART
  
PROSITE
  
PRINTS
 PR01084; NAHEXCHNGR.