| Tag | Content |
|---|
| CPLM ID | CPLM-024104 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Origin recognition complex subunit 1 |
Protein Synonyms/Alias | |
Gene Name | Orc1 |
Gene Synonyms/Alias | Orc1l |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 233 | IVIPNAKKSLELDGL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). |
Sequence Annotation | DOMAIN 44 170 BAH.
NP_BIND 513 520 ATP (Potential).
REGION 480 840 Necessary and sufficient for ORC complex
BINDING 93 93 Histone H4K20me2.
MOD_RES 276 276 Phosphoserine (By similarity).
MOD_RES 291 291 Phosphoserine (By similarity). |
Keyword | 3D-structure; ATP-binding; Complete proteome; DNA replication; DNA-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 840 AA |
Protein Sequence | MPSYLTRQKT RQTFSWVGRP LPNRKQFQQM YREICMKIND GSEIHIKVGQ FVLIQGEDNK 60
KPYVAKLIEL FQNGAEVPPK KCARVQWFVR FLEIPVSKRH LLGRSPPAQE IFWYDCSDWD 120
NKINVETIIG PVQVVALAPE EVIPVDQKSE ETLFVKLSWN KKDFAPLPPE VLAALREQED 180
SPEWQKPLKA KIKNVKSPAR NTTEQEVKGI KSNHSTSKFH QTPANIVIPN AKKSLELDGL 240
GFTRKPNTRW SKKSSCDSLD YQKTSKRRAA FSETTSPPKK PNKPREIKPS SALETRVKNG 300
QTQPFCAKSS VVLRARNPAM TTTKLGVDNT LSPIRNGLRS SVVPSGGLTP VYIRRKAKEQ 360
ETHKEPIRTS RVHRKSSLLT LKRIRQQLCL LDGDDRDQEE EESVDSESEE EDEFISSLPT 420
RNSLGQSRTR QTPSKSPQKN PKPRTPHRAT PQIRDRNLAV QEPASALEEA RLRLHVSAVP 480
DSLPCREQEF QDIYSFVESK LLDGTGGCMY ISGVPGTGKT ATVHEVIRCL QQAAETDDVP 540
PFQYVEVNGM KLTEPHQVYV QILKKLTGQK ATANHAAELL AKQFCGQGSQ KETTVLLVDE 600
LDLLWTHKQD VMYNLFDWPT HKGAHLIVLT IANTMDLPER IMMNRVSSRL GLTRMSFQPY 660
SHSQLKQILV SRLRNLRAFE DDAIQLVARK VAALSGDARR CLDICRRATE ICELSHLRGD 720
SLSLVTVAHL MEAIDEMFSS SYITAIKNSS VVEQSFLRAI IAEFRRSGLE EATFQQIYSQ 780
HVALCRMEGL PYPTMSETMA VCSRLGSCRL LLVEPSRNDL LLRVRLNVSQ NDVLFALKEE 840 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |