UniProt Accession

 MFSD1_HUMAN; Q9H3U5; B4DGJ8; B4DMR8; B4DU49; B4DWU1; C9JS94; J3KQL7; Q05C07; Q5XKJ1; Q8IVS1; Q8IXG4; Q9H7X1 

Genbank Protein ID

 AB014732; AF351617; AK024215; AK294628; AK297593; AK300497; AK301680; AC080013; AC128694; BC030542; BC042197 

Genbank Nucleotide ID

 BAB20269.1; AAN76517.2; BAB14852.1; BAG57809.1; BAG59980.1; BAG62211.1; BAG63153.1; AAH30542.1; AAH42197.1 

Protein Name

 Major facilitator superfamily domain-containing protein 1 

Protein Synonyms/Alias

 Smooth muscle cell-associated protein 4; SMAP-4 

Gene Name

 MFSD1 

Gene Synonyms/Alias

 SMAP4; UG0581B09 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
249	ILHKEQGKTGEVIKL	ubiquitination	[1, 2]
255	GKTGEVIKLTDVKDF	ubiquitination	[1, 2]
460	ARQREEIKFSHTE**	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 465 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 

Interpro

 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt. 

Pfam

 PF07690; MFS_1 

SMART

  

PROSITE

 PS50850; MFS 

PRINTS