| Tag | Content |
|---|
| CPLM ID | CPLM-021849 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Thyrotroph embryonic factor |
Protein Synonyms/Alias | |
Gene Name | Tef |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 38 | GSFPLVLKKLMENPP | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3' (By similarity). Also activates the telokin promoter in smooth muscle-specific and calcium-dependent manner. |
Sequence Annotation | DOMAIN 231 294 bZIP.
REGION 233 253 Basic motif (By similarity).
REGION 254 261 Leucine-zipper (By similarity).
MOD_RES 30 30 Phosphoserine (By similarity). |
Keyword | Activator; Alternative promoter usage; Biological rhythms; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 301 AA |
Protein Sequence | MSDAGGGKKP PVEPQAGPGP GRAAGERGLS GSFPLVLKKL MENPPRETRL DKEKGKEKLE 60
EDESAAASTM AVSASLMPPI WDKTIPYDGE SFHLEYMDLD EFLLENGIPA SPTHLAQNLL 120
LPVAELEGKE SASSSTASPP SSSTAIFQPS ETVSSTESSL EKERETPSPI DPSCVEVDVN 180
FNPDPADLVL SSVPGGELFN PRKHRFAEED LKPQPMIKKA KKVFVPDEQK DEKYWTRRKK 240
NNVAAKRSRD ARRLKENQIT IRAAFLEKEN TALRTEVAEL RKEVGKCKTI VSKYETKYGP 300
L 301 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003690; F:double-stranded DNA binding; IDA:MGI. GO:0043565; F:sequence-specific DNA binding; IEA:Compara. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0048511; P:rhythmic process; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |