CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029212
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Topoisomerase (DNA) II binding protein 1 
Protein Synonyms/Alias
  
Gene Name
 TOPBP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
137EVQQLTVKHGGQYMGubiquitination[1]
1334LLQSGGAKVLPGHSVubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Isomerase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1435 AA 
Protein Sequence
MHHQRCVPRA EHPVYNMVMS DVTISCTSLE KEKREEVHKY VQMMGGRVYR DLNVSVTHLI 60
AGEVGSKKYL VAANLKKPIL LPSWIKTLWE KSQEKKITRY TDINMEDFKC PIFLGCIICV 120
TGLCGLDRKE VQQLTVKHGG QYMGQLKMNE CTHLIVQEPK GQKYECAKRW NVHCVTTQWF 180
FDSIEKGFCQ DESIYKTEPR PEAKTMPNSS TPTSQINTID SRTLSDVSNI SNINASCVSE 240
SICNSLNSKL EPTLENLENL DVSAFQAPED LLDGCRIYLC GFSGRKLDKL RRLINSGGGV 300
RFNQLNEDVT HVIVGDYDDE LKQFWNKSAH RPHVVGAKWL LECFSKGYML SEEPYIHANY 360
QPVEIPVSHQ PESKAALLKK KNSSFSKKDF APSEKHEQAD EDLLSQYENG SSTVVEAKTS 420
EARPFNDSTH AEPLNDSTHI SLQEENQSSV SHCVPDVSTI TEEGLFSQKS FLVLGFSNEN 480
ESNIANIIKE NAGKIMSLLS RTVADYAVVP LLGCEVEATV GEVVTNTWLV TCIDYQTLFD 540
PKSNPLFTPV PVMTGMTPLE DCVISFSQCA GAEKESLTFL ANLLGASVQE YFVRKSNAKK 600
GMFASTHLIL KERGGSKYEA AKKWNLPAVT IAWLLETART GKRADESHFL IENSTKEERS 660
LETEITNGIN LNSDTAEHPG TRLQTHRKTV VTPLDMNRFQ SKAFRAVVSQ HARQVAASPA 720
VGQPLQKEPS LHLDTPSKFL SKDKLFKPSF DVKDALAALE TPGRPSQQKR KPSTPLSEVI 780
VKNLQLALAN SSRNAVALSA SPQLKEAQSE KEEAPKPLHK VVVCVSKKLS KKQSELNGIA 840
ASLGADYRWS FDETVTHFIY QGRPNDTNRE YKSVKERGVH IVSEHWLLDC AQECKHLPES 900
LYPHTYNPKM SLDISAVQDG RLCNSRLLSA VSSTKDDEPD PLILEENDVD NMATNNKESA 960
PSNGSGKNDS KGVLTQTLEM RENFQKQLQE IMSATSIVKP QGQRTSLSRS GCNSASSTPD 1020
STRSARSGRS RVLEALRQSR QTVPDVNTEP SQNEQIIWDD PTAREERARL ASNLQWPSCP 1080
TQYSELQVDI QNLEDSPFQK PLHDSEIAKQ AVCDPGNIRV TEAPKHPISE ELETPIKDSH 1140
LIPTPQAPSI AFPLANPPVA PHPREKIITI EETHEELKKQ YIFQLSSLNP QERIDYCHLI 1200
EKLGGLVIEK QCFDPTCTHI VVGHPLRNEK YLASVAAGKW VLHRSYLEAC RTAGHFVQEE 1260
DYEWGSSSIL DVLTGINVQQ RRLALAAMRW RKKIQQRQES GIVEGAFSGW KVILHVDQSR 1320
EAGFKRLLQS GGAKVLPGHS VPLFKEATHL FSDLNKLKPD DSGVNIAEAA AQNVYCLRTE 1380
YIADYLMQES PPHVENYCLP EAISFIQNNK ELGTGLSQKR KAPTEKNKIK RPRVH 1435 
Gene Ontology
 GO:0016853; F:isomerase activity; IEA:UniProtKB-KW. 
Interpro
 IPR001357; BRCT_dom.
 IPR016126; Secretoglobin.
 IPR026993; Topbp1. 
Pfam
 PF00533; BRCT
 PF12738; PTCB-BRCT 
SMART
 SM00292; BRCT 
PROSITE
 PS50172; BRCT 
PRINTS