UniProt Accession

 MGST1_RAT; P08011 

Genbank Protein ID

 J03752; BC063150 

Genbank Nucleotide ID

 AAA41281.1; AAH63150.1 

Protein Name

 Microsomal glutathione S-transferase 1 

Protein Synonyms/Alias

 Microsomal GST-1; Microsomal GST-I 

Gene Name

 Mgst1 

Gene Synonyms/Alias

 Gst12 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
68	KFLRTDEKVERVRRA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 BINDING 38 38 Glutathione.
 BINDING 73 73 Glutathione.
 BINDING 74 74 Glutathione.
 BINDING 76 76 Glutathione.
 BINDING 81 81 Glutathione.
 BINDING 121 121 Glutathione.
 MOD_RES 42 42 N6-acetyllysine (By similarity).
 MOD_RES 55 55 N6-acetyllysine (By similarity).
 MOD_RES 93 93 Nitrated tyrosine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Membrane; Microsome; Mitochondrion; Mitochondrion outer membrane; Nitration; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 155 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IDA:RGD.
 GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005778; C:peroxisomal membrane; IDA:RGD.
 GO:0043295; F:glutathione binding; IDA:UniProtKB.
 GO:0004602; F:glutathione peroxidase activity; IEA:Compara.
 GO:0004364; F:glutathione transferase activity; TAS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0071449; P:cellular response to lipid hydroperoxide; IEA:Compara.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0033327; P:Leydig cell differentiation; IEP:RGD.
 GO:0070207; P:protein homotrimerization; IDA:UniProtKB.
 GO:0042493; P:response to drug; IDA:RGD.
 GO:0032496; P:response to lipopolysaccharide; IDA:RGD.
 GO:0010243; P:response to organic nitrogen; IDA:RGD. 

Interpro

 IPR023352; MAPEG-like_dom.
 IPR001129; Membr-assoc_MAPEG. 

Pfam

 PF01124; MAPEG 

SMART

  

PROSITE

  

PRINTS