CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032182
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ53276, moderately similar to DNA replication licensing factor MCM2 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
450KMITSLSKDQQIGEKubiquitination[1]
663QQSISISKAGIVTSLubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; DNA replication; DNA-binding; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 954 AA 
Protein Sequence
MAESSESFTM ASSPAQRRRG NDPLTSSPGR SSRRTDALTS SPGRDLPPFE DESEGLLGTE 60
GPLEEEEDGE ELIGDGMERD YRAIPELDAY EAEGLALDDE DVEELTASQR EAGRGLLYDS 120
DEEDEERPAR KRRQVERATE DGEEDEEMIE SIENLEDLKG HSVREWVSMA GPRLEIHHRF 180
KNFLRTHVDS HGHNVFKERI SDMCKENRES LVVNYEDLAA REHVLAYFLP EAPAELLQIF 240
DEAALEVVLA MYPKYDRITN HIHVRISHLP LVEELRSLRQ LHLNQLIRTS GVVTSCTGVL 300
PQLSMVKYNC NKCNFVLGPF CQSQNQEVKP GSCPECQSAG PFEVNMEETI YQNYQRIRIQ 360
ESPGKVAAGR LPRSKDAILL ADLVDSCKPG DEIELTGIYH NNYDGSLNTA NGFPVFATVI 420
LANHVAKKDN KVAVGELTDE DVKMITSLSK DQQIGEKESS RNASLAEAGI GAIPSQLLAI 480
EPSLRRSGVP IGEVGVSQRQ EARSFSSANT HWFLEDLLGP SCRDTMIFAS IAPSIYGHED 540
IKRGLALALF GGEPKNPGGK HKVRGDINVL LCGDPGTAKS QFLKYIEKVS SRAIFTTGQG 600
ASAVGLTAYV QRHPVSREWT LEAGALVLAD RGVCLIDEFD KMNDQDRTSI HEAMEQQSIS 660
ISKAGIVTSL QARCTVIAAA NPIGGRYDPS LTLSENVDLT EPIISRFDIL CVVRDTVDPV 720
QDEMLARFVV GSHVRHHPSN KEEEGLANGS AAEPAMPNTY GVEPLPQEVL KKYIIYAKER 780
VHPKLNQMDQ DKVAKMYSDL RKESMATGSI PITVRHIESM IRMAEAHARI HLRDYVIEDD 840
VNMAIRVMLE SFIDTQKFSV MRSMRKTFAR YLSFRRDNNE LLLFILKQLV AEQVTYQRNR 900
FGAQQDTIEV PEKDLVDKAR QINIHNLSAF YDSELFRMNK FSHDLKRKMI LQQF 954 
Gene Ontology
 GO:0042555; C:MCM complex; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003678; F:DNA helicase activity; IEA:InterPro.
 GO:0032508; P:DNA duplex unwinding; IEA:GOC.
 GO:0006270; P:DNA replication initiation; IEA:InterPro. 
Interpro
 IPR008045; MCM2.
 IPR018525; MCM_CS.
 IPR001208; MCM_DNA-dep_ATPase.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00493; MCM
 PF12619; MCM2_N 
SMART
 SM00350; MCM 
PROSITE
 PS00847; MCM_1
 PS50051; MCM_2 
PRINTS
 PR01657; MCMFAMILY.
 PR01658; MCMPROTEIN2.