CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023012
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Potassium voltage-gated channel subfamily G member 1 
Protein Synonyms/Alias
 Voltage-gated potassium channel subunit Kv6.1; kH2 
Gene Name
 KCNG1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
327GAAAGRRKPGAGNSYubiquitination[1]
471SRSYLELKQEQERVMubiquitination[1, 2]
489AQFLIKTKSQLSVSQubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity. 
Sequence Annotation
 MOTIF 424 429 Selectivity filter (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Ion channel; Ion transport; Membrane; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 513 AA 
Protein Sequence
MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED 60
RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD ILNVCDDYDV TCNEFFFDRN 120
PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV 180
EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT 240
AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP 300
LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS 360
LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI 420
TMTTVGYGDM VPRSTPGQVV ALSSILSGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR 480
RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN 513 
Gene Ontology
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
 GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome.
 GO:0051260; P:protein homooligomerization; IEA:InterPro.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR003091; K_chnl.
 IPR003968; K_chnl_volt-dep_Kv.
 IPR003969; K_chnl_volt-dep_Kv6.
 IPR003131; T1-type_BTB. 
Pfam
 PF00520; Ion_trans
 PF02214; K_tetra 
SMART
 SM00225; BTB 
PROSITE
  
PRINTS
 PR00169; KCHANNEL.
 PR01492; KV6CHANNEL.
 PR01491; KVCHANNEL.