CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033539
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 42 
Protein Synonyms/Alias
  
Gene Name
 USP42 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
173FANFTGGKIAKDVKYubiquitination[1, 2, 3]
176FTGGKIAKDVKYPEYubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1044 AA 
Protein Sequence
MMCTMQAHIT QALSNPGDVI KPMFVINEMR RIARHFRFGN QEDAHEFLQY TVDAMQKACL 60
NGSNKLDRHT QATTLVCQIF GGYLRSRVKC LNCKGVSDTF DPYLDITLEI KAAQSVNKAL 120
EQFVKPEQLD GENSYKCSKC KKMVPASKRF TIHRSSNVLT LSLKRFANFT GGKIAKDVKY 180
PEYLDIRPYM SQPNGEPIVY VLYAVLVHTG FNCHAGHYFC YIKASNGLWY QMNDSIVSTS 240
DIRSVLSQQA YVLFYIRSHD VKNGGELTHP THSPGQSSPR PVISQRVVTN KQAAPGFIGP 300
QLPSHMIKNP PHLNGTGPLK DTPSSSMSSP NGNSSVNRAS PVNASASVQN WSVNRSSVIP 360
EHPKKQKITI SIHNKLPVRQ CQSQPNLHSN SLENPTKPVP SSTITNSAVQ STSNASTMSV 420
SSKVTKPIPR SESCSQPVMN GKSKLNSSVL VPYGAESSED SDEESKGLGK ENGIGTIVSS 480
HSPGQDAEDE EATPHELQEP MTLNGANSAD SDSDPKENGL APDGASCQGQ PALHSENPFA 540
KANGLPGKLM PAPLLSLPED KILETFRLSN KLKGSTDEMS APGAERGPPE DRDAEPQPGS 600
PAAESLEEPD AAAGLSSTKK APPPRDPGTP ATKEGAWEAM AVAPEEPPPS AGEDIVGDTA 660
PPDLCDPGSL TGDASPLSQD AKGMIAEGPR DSALAEAPEG LSPAPPARSE EPCEQPLLVH 720
PSGDHARDAQ DPSQSLGAPE AAERPPAPVL DMAPAGHPEG DAEPSPGERV EDAAAPKAPG 780
PSPAKEKIGS LRKVDRGHYR SRRERSSSGE PARESRSKTE GHRHRRRRTC PRERDRQDRH 840
APEHHPGHGD RLSPGERRSL GRCSHHHSRH RSGVELDWVR HHYTEGERGW GREKFYPDRP 900
RWDRCRYYHD RYALYAARDW KPFHGGREHE RAGLHERPHK DHNRGRRGCE PARERERHRP 960
SSPRAGAPHA LAPHPDRFSH DRTALVAGDN CNLSDRFHEH ENGKSRKRRH DSVENSDSHV 1020
EKKARRSEQK DPLEEPKAKK HKKS 1044 
Gene Ontology
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0016579; P:protein deubiquitination; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS