UniProt Accession

 DYL2_HUMAN; Q96FJ2; B2R5B4 

Genbank Protein ID

 AF112997; AK312125; CH471109; BC010744 

Genbank Nucleotide ID

 AAP97230.1; BAG35061.1; EAW94484.1; AAH10744.1 

Protein Name

 Dynein light chain 2, cytoplasmic 

Protein Synonyms/Alias

 8 kDa dynein light chain b; DLC8b; Dynein light chain LC8-type 2 

Gene Name

 DYNLL2 

Gene Synonyms/Alias

 DLC2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MSDRKAVIKNAD	acetylation	[1]
31	CATQAMEKYNIEKDI	ubiquitination	[2, 3]
36	MEKYNIEKDIAAYIK	acetylation	[3, 4]
36	MEKYNIEKDIAAYIK	ubiquitination	[5, 6]
49	IKKEFDKKYNPTWHC	ubiquitination	[6]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 89 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0016459; C:myosin complex; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0003774; F:motor activity; IEA:UniProtKB-KW.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:Reactome.
 GO:0007017; P:microtubule-based process; IEA:InterPro.
 GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome.
 GO:0008039; P:synaptic target recognition; IEA:Compara.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR019763; Dynein_light_1/2_CS.
 IPR001372; Dynein_light_chain_typ-1/2. 

Pfam

 PF01221; Dynein_light 

SMART

  

PROSITE

 PS01239; DYNEIN_LIGHT_1 

PRINTS