| Tag | Content |
|---|
| CPLM ID | CPLM-003913 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coproporphyrinogen-III oxidase |
Protein Synonyms/Alias | COX; Coprogen oxidase; Coproporphyrinogenase |
Gene Name | HEM13 |
Gene Synonyms/Alias | YDR044W; YD5112.02 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 100 | LRLPEDPKTGLPVTD | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity). |
Sequence Annotation | REGION 57 66 Important for dimerization (By
REGION 133 135 Substrate binding (By similarity).
REGION 266 302 Important for dimerization (By
REGION 285 290 Substrate binding (By similarity).
ACT_SITE 131 131 Proton donor (By similarity).
BINDING 117 117 Substrate (By similarity).
DISULFID 193 193 Interchain. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Heme biosynthesis; Oxidoreductase; Porphyrin biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 328 AA |
Protein Sequence | MPAPQDPRNL PIRQQMEALI RRKQAEITQG LESIDTVKFH ADTWTRGNDG GGGTSMVIQD 60
GTTFEKGGVN VSVVYGQLSP AAVSAMKADH KNLRLPEDPK TGLPVTDGVK FFACGLSMVI 120
HPVNPHAPTT HLNYRYFETW NQDGTPQTWW FGGGADLTPS YLYEEDGQLF HQLHKDALDK 180
HDTALYPRFK KWCDEYFYIT HRKETRGIGG IFFDDYDERD PQEILKMVED CFDAFLPSYL 240
TIVKRRKDMP YTKEEQQWQA IRRGRYVEFN LIYDRGTQFG LRTPGSRVES ILMSLPEHAS 300
WLYNHHPAPG SREAKLLEVT TKPREWVK 328 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0004109; F:coproporphyrinogen oxidase activity; IDA:SGD. GO:0042803; F:protein homodimerization activity; ISS:UniProtKB. GO:0006783; P:heme biosynthetic process; IMP:SGD. GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. |
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