UniProt Accession

 HNRPF_MOUSE; Q9Z2X1; Q5FWK2; Q8BVU8; Q8K2U9; Q8R0E7 

Genbank Protein ID

 AK076478; BC018185; BC025481; BC027003; BC029163; BC029764; BC033483; BC089313 

Genbank Nucleotide ID

 BAC36361.1; AAH18185.1; AAH25481.1; AAH27003.1; AAH29163.1; AAH29764.1; AAH33483.1; AAH89313.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein F 

Protein Synonyms/Alias

 hnRNP F; Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 

Gene Name

 Hnrnpf 

Gene Synonyms/Alias

 Hnrpf 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
87	HRYIEVFKSHRTEMD	ubiquitination	[1]
98	TEMDWVLKHSGPNSA	ubiquitination	[1]
167	ASQELAEKALGKHKE	ubiquitination	[1]
185	HRYIEVFKSSQEEVR	ubiquitination	[1]
200	SYSDPPLKFMSVQRP	ubiquitination	[1]
224	RRYIGIVKQAGLDRM	ubiquitination	[1]
299	HMRGLPYKATENDIY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). 

Sequence Annotation

 DOMAIN 11 90 RRM 1.
 DOMAIN 111 188 RRM 2.
 DOMAIN 289 366 RRM 3.
 REGION 81 86 Interaction with RNA (By similarity).
 REGION 179 184 Interaction with RNA (By similarity).
 REGION 355 360 Interaction with RNA (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylmethionine; in Heterogeneous
 MOD_RES 104 104 Phosphoserine (By similarity).
 MOD_RES 161 161 Phosphoserine (By similarity).
 MOD_RES 187 187 Phosphoserine (By similarity).
 MOD_RES 224 224 N6-acetyllysine (By similarity).
 CROSSLNK 72 72 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Isopeptide bond; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 415 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003727; F:single-stranded RNA binding; ISS:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR012996; Znf_CHHC. 

Pfam

 PF08080; zf-RNPHF 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS