CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033151
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transportin-3 
Protein Synonyms/Alias
 Uncharacterized protein 
Gene Name
 TNPO3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
27HDPDPSGKERASFWLubiquitination[1]
68YFAAQTMKMKIQTSFubiquitination[1]
547LMKGLCEKPLASAAAubiquitination[1, 2]
555PLASAAAKAIHNICSubiquitination[1]
628VQVMALKKLLSQEPSubiquitination[1, 3, 4]
911RWLENSLKGLPKETTubiquitination[1]
934KQLTDFHKQVTSAEEacetylation[2]
934KQLTDFHKQVTSAEEubiquitination[1]
943VTSAEECKQVCWALRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 957 AA 
Protein Sequence
MEGAKPTLQL VYQAVQALYH DPDPSGKERA SFWLGELQRS VHAWEISDQL LQIRQDVESC 60
YFAAQTMKMK IQTSFYELPT DSHASLRDSL LTHIQNLKDL SPVIVTQLAL AIADLALQMP 120
SWKGCVQTLV EKYSNDVTSL PFLLEILTVL PEEVHSRSLR IGANRRTEII EDLAFYSSTV 180
VSLLMTCVEK AGTDEKMLMK VFRCLGSWFN LGVLDSNFMA NNKLLALLFE VLQQDKTSSN 240
LHEAASDCVC SALYAIENVE TNLPLAMQLF QGVLTLETAY HMAVAREDLD KVLNYCRIFT 300
ELCETFLEKI VCTPGQGLGD LRTLELLLIC AGHPQYEVVE ISFNFWYRLG EHLYKTNDEV 360
IHGIFKAYIQ RLLHALARHC QLEPDHEGVP EETDDFGEFR MRVSDLVKDL IFLIGSMECF 420
AQLYSTLKEG NPPWEVTEAV LFIMAAIAKS VDPKKPFSNA VCRHSLLFGQ NITSEISNCE 480
YLPPVLRENN PTLVEVLEGV VRLPETVHTA VRYTSIELVG EMSEVVDRNP QFLDPVLGYL 540
MKGLCEKPLA SAAAKAIHNI CSVCRDHMAQ HFNGLLEIAR SLDSFLLSPE AAVGLLKGTA 600
LVLARLPLDK ITECLSELCS VQVMALKKLL SQEPSNGISS DPTVFLDRLA VIFRHTNPIV 660
ENGQTHPCQK VIQEIWPVLS ETLNKHRADN RIVERCCRCL RFAVRCVGKG SAALLQPLVT 720
QMVNVYHVHQ HSCFLYLGSI LVDEYGMEEG CRQGLLDMLQ ALCIPTFQLL EQQNGLQNHP 780
DTVDDLFRLA TRFIQRSPVT LLRSQVVIPI LQWAIASTTL DHRDANCSVM RFLRDLIHTG 840
VANDHEEDFE LRKELIGQVM NQLGQQLVSQ LLHTCCFCLP PYTLPDVAEV LWEIMQVDRP 900
TFCRWLENSL KGLPKETTVG AVTVTHKQLT DFHKQVTSAE ECKQVCWALR DFTRLFR 957 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR013598; Exportin-1/Importin-b-like. 
Pfam
 PF08389; Xpo1 
SMART
  
PROSITE
  
PRINTS