UniProt Accession

 STC2_HUMAN; O76061 

Genbank Protein ID

 AF055460; AB012664; AF098462; AF031036; BT019591; BC000658; BC006352; BC013958 

Genbank Nucleotide ID

 AAC27036.1; BAA33489.1; AAC97948.1; AAD01922.1; AAV38398.1; AAH00658.1; AAH06352.1; AAH13958.1 

Protein Name

 Stanniocalcin-2 

Protein Synonyms/Alias

 STC-2; Stanniocalcin-related protein; STC-related protein; STCRP 

Gene Name

 STC2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	GKFDAQGKSFIKDAL	ubiquitination	[1]
142	LQRECYLKHDLCAAA	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Has an anti-hypocalcemic action on calcium and phosphate homeostasis. 

Sequence Annotation

 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 302 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005179; F:hormone activity; TAS:ProtInc.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0046697; P:decidualization; IEA:Compara.
 GO:0007566; P:embryo implantation; IEA:Compara.
 GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Compara.
 GO:0040015; P:negative regulation of multicellular organism growth; IEA:Compara.
 GO:2001256; P:regulation of store-operated calcium entry; IEA:Compara.
 GO:0007584; P:response to nutrient; TAS:ProtInc.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0033280; P:response to vitamin D; IEA:Compara. 

Interpro

 IPR004978; Stanniocalcin. 

Pfam

 PF03298; Stanniocalcin 

SMART

  

PROSITE

  

PRINTS