| Tag | Content |
|---|
| CPLM ID | CPLM-016490 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | tRNA wybutosine-synthesizing protein 1 homolog |
Protein Synonyms/Alias | Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; tRNA-yW-synthesizing protein |
Gene Name | Tyw1 |
Gene Synonyms/Alias | Rsafd1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 385 | RGRGGCYKHTFYGIE | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). |
Sequence Annotation | DOMAIN 71 229 Flavodoxin-like.
NP_BIND 77 81 FMN (By similarity).
NP_BIND 168 200 FMN (By similarity).
METAL 405 405 Iron-sulfur (4Fe-4S-S-AdoMet)
METAL 409 409 Iron-sulfur (4Fe-4S-S-AdoMet)
METAL 412 412 Iron-sulfur (4Fe-4S-S-AdoMet) |
Keyword | 4Fe-4S; Alternative splicing; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Reference proteome; S-adenosyl-L-methionine; tRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 721 AA |
Protein Sequence | MGPLDVWDLS PLLSLWMNRF YIYMGCALGL TLCICVQIIK KQVTRSQEKR VPGAPDSSLS 60
PQKKQTHVSG VKIFYGSQTG TAKGFAVVLA KAVTSLDLPV AIINLKEYDP DDSLIGEITS 120
KTVCAFLVAT YTDGCPTESA EWFCKWLEES ANDFRFGKTY LKGLRYAVFG LGDSAYRSHF 180
NKVSTNVDKW LWMLGAQRVL TRGEGDCNAV QSKHGSIEAD FTAWKTKFIS RLQALQRGEK 240
KACGGNCKRG KCESAQHGPG EARPHPQGEL HPGDAEEEEP CESSSEDELG TQDYQSLTSV 300
VDVEDLGNIM NPVKREKREK SHQDGKAAMQ RNPEKTEDGE GRAMITPALR EALTKQGYQL 360
IGSHSGVKLC RWTKSMLRGR GGCYKHTFYG IESHRCMEAT PSLACANKCV FCWRHHTNPV 420
GTEWRWKMDQ PELILKEAIE NHQNMIKQFK GVPGLKAERF EEGMEVKHCA LSLVGEPIMY 480
PEINRLLKLL HQHGISSFLV TNAQFPEEIR KLTPVTQLYV SVDASTRDGL KKIDRPLFKD 540
FWQRFLDSLK ALSAKQQRTV YRLTLVKCWN VDELQAYAEL VSLGNPDFIE VKGVTYCGES 600
AASSLTMANV PWHEEVVRFV RELVDLLPDY EVACEHEHSN CLLIGHKKFK IDGEWWTWIN 660
YSRFQELVLQ YEESGGSKTF SSRDYMARTP QWALFGARER GFDPKDTRYQ RKNKTKDISG 720
C 721 |
Gene Ontology | GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. GO:0010181; F:FMN binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0016491; F:oxidoreductase activity; IEA:InterPro. GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |